| Title: |
Shedding light on the shadows: oxidative stress and its pivotal role in prostate cancer progression |
| Authors: |
Marek Biesiadecki, Mateusz Mołoń, Krzysztof Balawender, Zofia Kobylińska, Sabina Galiniak |
| Source: |
Frontiers in Oncology, Vol 14 (2024) |
| Publisher Information: |
Frontiers Media S.A., 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
oxidative stress, nitrosative stress, oxidative damage of protein, prostate cancer, cancer progression, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
ObjectivesData on oxidative protein damage, total antioxidant capacity (TAC) and lipid peroxidation in progression of prostate cancer remain elusive. So far, the influence of the presence of perineural invasion on the level of oxidative stress has not been described. Additionally, there is limited data on the level of oxidative stress in patients’ urine.MethodsWe compared the levels of oxidative stress markers in serum and urine in 50 patients with prostate cancer depending on the tumor stage and histological grade, the Gleason score, and the presence of perineural invasion.ResultsWe found a significantly de-creased level of serum thiol groups and TAC in participants with prostate cancer. Similarly, serum Amadori products and malondialdehyde (MDA) were higher in patients than in healthy men. There was a significantly decrease in TAC and a significantly increased MDA in the urine of prostate cancer patients. As the stage of cancer increased, a decrease in the thiol group concentration and TAC as well as an increase in the concentration of lipid peroxidation products in the serum was observed. The serum level of advanced oxidation protein products (AOPP) increased in the group with Gleason scores greater than 7. Furthermore, serum thiol groups and TAC were reduced in the group with Gleason >7 as compared to Gleason |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2234-943X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fonc.2024.1393078/full; https://doaj.org/toc/2234-943X |
| DOI: |
10.3389/fonc.2024.1393078 |
| Access URL: |
https://doaj.org/article/baf8443dece24b548e61381009b14d80 |
| Accession Number: |
edsdoj.baf8443dece24b548e61381009b14d80 |
| Database: |
Directory of Open Access Journals |
