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Emergence and Genomic Features of a mcr-1 Escherichia coli from Duck in Hungary

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Title: Emergence and Genomic Features of a mcr-1 Escherichia coli from Duck in Hungary
Authors: Ama Szmolka, Ákos Gellért, Dóra Szemerits, Fanni Rapcsák, Sándor Spisák, András Adorján
Source: Antibiotics, Vol 12, Iss 10, p 1519 (2023)
Publisher Information: MDPI AG, 2023.
Publication Year: 2023
Collection: LCC:Therapeutics. Pharmacology
Subject Terms: mcr-1 Escherichia coli, colistin resistance, waterfowl, plasmid genome, core genome MLST, multiresistance, Therapeutics. Pharmacology, RM1-950
More Details: Plasmids carrying high-risk resistance mechanisms in pathogenic E. coli have gained particular attention in veterinary medicine, especially since the discovery of the colistin resistance gene, mcr-1. Here, we provide the first evidence of its emergence and describe the complete mcr-1 plasmid sequence of a multi-resistant avian pathogenic E. coli (APEC) strain from waterfowl in Hungary. Whole-genome sequencing analysis and core-genome MLST were performed to characterize the genome structure of the mcr-1 plasmid and to reveal the phylogenetic relation between the Hungarian duck strain Ec45-2020 and the internationally circulating mcr-1-positive E. coli strains from poultry and humans. Results showed that plasmid pEc45-2020-33kb displayed a high level of genome identity with mcr-1 plasmids of IncX4 type widespread among human, animal and food reservoirs of enteric bacteria of public health. The mcr-1-positive E. coli strain Ec45-2020 belongs to the ST162 genotype, considered as one of the globally disseminated zoonotic genotypes of MDR E. coli. In accordance with international findings, our results underline the importance of continuous surveillance of enteric bacteria with high-risk antimicrobial resistance genotypes, including neglected animals, such as waterfowls, as possible reservoirs for the colistin resistance gene mcr-1.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2079-6382
Relation: https://www.mdpi.com/2079-6382/12/10/1519; https://doaj.org/toc/2079-6382
DOI: 10.3390/antibiotics12101519
Access URL: https://doaj.org/article/aba65cc2a0944dba81d3c9830e9c4a06
Accession Number: edsdoj.ba65cc2a0944dba81d3c9830e9c4a06
Database: Directory of Open Access Journals
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  Data: Emergence and Genomic Features of a mcr-1 Escherichia coli from Duck in Hungary
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  Data: <searchLink fieldCode="AR" term="%22Ama+Szmolka%22">Ama Szmolka</searchLink><br /><searchLink fieldCode="AR" term="%22Ákos+Gellért%22">Ákos Gellért</searchLink><br /><searchLink fieldCode="AR" term="%22Dóra+Szemerits%22">Dóra Szemerits</searchLink><br /><searchLink fieldCode="AR" term="%22Fanni+Rapcsák%22">Fanni Rapcsák</searchLink><br /><searchLink fieldCode="AR" term="%22Sándor+Spisák%22">Sándor Spisák</searchLink><br /><searchLink fieldCode="AR" term="%22András+Adorján%22">András Adorján</searchLink>
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  Data: Antibiotics, Vol 12, Iss 10, p 1519 (2023)
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  Data: MDPI AG, 2023.
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  Data: <searchLink fieldCode="DE" term="%22mcr-1+Escherichia+coli%22">mcr-1 Escherichia coli</searchLink><br /><searchLink fieldCode="DE" term="%22colistin+resistance%22">colistin resistance</searchLink><br /><searchLink fieldCode="DE" term="%22waterfowl%22">waterfowl</searchLink><br /><searchLink fieldCode="DE" term="%22plasmid+genome%22">plasmid genome</searchLink><br /><searchLink fieldCode="DE" term="%22core+genome+MLST%22">core genome MLST</searchLink><br /><searchLink fieldCode="DE" term="%22multiresistance%22">multiresistance</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%2E+Pharmacology%22">Therapeutics. Pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22RM1-950%22">RM1-950</searchLink>
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  Data: Plasmids carrying high-risk resistance mechanisms in pathogenic E. coli have gained particular attention in veterinary medicine, especially since the discovery of the colistin resistance gene, mcr-1. Here, we provide the first evidence of its emergence and describe the complete mcr-1 plasmid sequence of a multi-resistant avian pathogenic E. coli (APEC) strain from waterfowl in Hungary. Whole-genome sequencing analysis and core-genome MLST were performed to characterize the genome structure of the mcr-1 plasmid and to reveal the phylogenetic relation between the Hungarian duck strain Ec45-2020 and the internationally circulating mcr-1-positive E. coli strains from poultry and humans. Results showed that plasmid pEc45-2020-33kb displayed a high level of genome identity with mcr-1 plasmids of IncX4 type widespread among human, animal and food reservoirs of enteric bacteria of public health. The mcr-1-positive E. coli strain Ec45-2020 belongs to the ST162 genotype, considered as one of the globally disseminated zoonotic genotypes of MDR E. coli. In accordance with international findings, our results underline the importance of continuous surveillance of enteric bacteria with high-risk antimicrobial resistance genotypes, including neglected animals, such as waterfowls, as possible reservoirs for the colistin resistance gene mcr-1.
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  Data: https://www.mdpi.com/2079-6382/12/10/1519; https://doaj.org/toc/2079-6382
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