Toxicological Assessment of Solanum Erianthum Extracts in Albino Rats: Haematological, Biochemical and Histopathological Findings

Bibliographic Details
Title:	Toxicological Assessment of Solanum Erianthum Extracts in Albino Rats: Haematological, Biochemical and Histopathological Findings
Authors:	Ngozi Maureen Uzoekwe, Ikechukwu Peter Ejidike, Mark Ehijele Ukhun
Source:	Iranian Journal of Toxicology, Vol 15, Iss 1, Pp 37-48 (2021)
Publisher Information:	Arak University of Medical Sciences, 2021.
Publication Year:	2021
Collection:	LCC:Toxicology. Poisons
Subject Terms:	solanum erianthum, hepatic macrophages, serum chemistry, toxicity, sinus histiocytosis, enzymatic activities, Toxicology. Poisons, RA1190-1270
More Details:	Background: Solanum erianthum leaves extract has been used to treat sexually-transmitted diseases, malaria, and leprosy. This study assessed the toxicity and safety of S. erianthum extract in rats. Methods: Treatment with 250, 500 or 750 mg/kg of the aqueous, ethanolic and methanolic extracts in the rats had different effects on the biochemical activities of the liver, heart and kidneys, and based on the hematological and histopathological changes observed after short-term (30 days) and long-term (60 days) exposure. Results: The serum biochemical parameters examined were AST, ALT, and ALP concentrations in the albino rats treated with the extracts of S. Erianthum at various concentrations. The extract showed significantly different effects in the treated versus untreated rats (P
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	2008-2967 2251-9459
Relation:	http://ijt.arakmu.ac.ir/article-1-890-en.html; https://doaj.org/toc/2008-2967; https://doaj.org/toc/2251-9459
Access URL:	https://doaj.org/article/ab9fad4e624145afb227f6e88aac218c
Accession Number:	edsdoj.b9fad4e624145afb227f6e88aac218c
Database:	Directory of Open Access Journals

More Details
ISSN:	20082967 22519459
Published in:	Iranian Journal of Toxicology
Language:	English