The Chemical Modification to Improve Solubility of Chitosan and Its Derivatives Application, Preparation Method, Toxicity as a Nanoparticles

Bibliographic Details
Title:	The Chemical Modification to Improve Solubility of Chitosan and Its Derivatives Application, Preparation Method, Toxicity as a Nanoparticles
Authors:	Suryani S, Chaerunisaa AY, Joni IM, Ruslin R, Aspadiah V, Anton A, Sartinah A, Ramadhan LOAN
Source:	Nanotechnology, Science and Applications, Vol Volume 17, Pp 41-57 (2024)
Publisher Information:	Dove Medical Press, 2024.
Publication Year:	2024
Collection:	LCC:Medical technology LCC:Chemical technology
Subject Terms:	polymer, chitosan derivatives, solubility enhancement, drug delivery system, Medical technology, R855-855.5, Chemical technology, TP1-1185
More Details:	Suryani Suryani,1,2 Anis Yohana Chaerunisaa,3,4 I Made Joni,5,6 Ruslin Ruslin,2 Vica Aspadiah,2 Anton Anton,7 Ari Sartinah,2 La Ode Ahmad Nur Ramadhan8 1Doctor of Pharmacy Study Program, Faculty of Pharmacy, Padjadjaran University, Sumedang, Indonesia; 2Department of Pharmacy, Faculty of Pharmacy, Halu Oleo University, Kendari, Indonesia; 3Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Padjadjaran University, Sumedang, Indonesia; 4Dosage Form Development Research Centre, Faculty of Pharmacy, Padjadjaran University, Sumedang, Indonesia; 5Department of Physics, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Sumedang, Indonesia; 6Functional Nano Powder University Centre of Excellence, Padjadjaran University, Sumedang, Indonesia; 7Department of Biology, Faculty of Mathematics and Natural Sciences, Halu Oleo University, Kendari, Indonesia; 8Department of Chemistry, Faculty of Mathematics and Natural Sciences, Halu Oleo University, Kendari, IndonesiaCorrespondence: Anis Yohana Chaerunisaa; Suryani Suryani, Email anis.yohana.chaerunisaa@unpad.ac.id; Suryani20001@mail.unpad.ac.idAbstract: Chitosan is a functional polymer in the pharmaceutical field, including for nanoparticle drug delivery systems. Chitosan-based nanoparticles are a promising carrier for a wide range of therapeutic agents and can be administered in various routes. Solubility is the main problem for its production and utilization in large-scale industries. Chitosan modifications have been employed to enhance its solubility, including chemical modification. Many reviews have reported the chemical modification but have not focused on the specific characteristics obtained. This review focused on the modification to improve chitosan solubility. Additionally, this review also focused on the application of chitosan derivatives in nanoparticle drug delivery systems since very few similar reviews have been reported. The specific method for chitosan derivative-based nanoparticles was also reported and the latest report of chitosan, chitosan derivative, and chitosan toxicity were also described. Keywords: polymer, chitosan derivatives, solubility enhancement, drug delivery system
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	1177-8903
Relation:	https://www.dovepress.com/the-chemical-modification-to-improve-solubility-of-chitosan-and-its-de-peer-reviewed-fulltext-article-NSA; https://doaj.org/toc/1177-8903
Access URL:	https://doaj.org/article/b9950d104b4d4bba9d7ad70ab1b3b393
Accession Number:	edsdoj.b9950d104b4d4bba9d7ad70ab1b3b393
Database:	Directory of Open Access Journals

More Details
ISSN:	11778903
Published in:	Nanotechnology, Science and Applications
Language:	English