Academic Journal
Outcome of necrotizing fasciitis and Fournier's gangrene with and without hyperbaric oxygen therapy: a retrospective analysis over 10 years
| Title: | Outcome of necrotizing fasciitis and Fournier's gangrene with and without hyperbaric oxygen therapy: a retrospective analysis over 10 years |
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| Authors: | Assen Mladenov, Katharina Diehl, Oliver Müller, Christian von Heymann, Susanne Kopp, Wiebke K. Peitsch |
| Source: | World Journal of Emergency Surgery, Vol 17, Iss 1, Pp 1-16 (2022) |
| Publisher Information: | BMC, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Surgery LCC:Medical emergencies. Critical care. Intensive care. First aid |
| Subject Terms: | Fournier's gangrene, Debridement, Hyperbaric oxygen therapy, Necrotizing fasciitis, Necrotizing soft tissue infections, Vacuum-assisted wound closure, Surgery, RD1-811, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9 |
| More Details: | Abstract Background Necrotizing soft tissue infections (NSTI) require immediate radical debridement, broad-spectrum antibiotics and intensive care. Hyperbaric oxygen therapy (HBOT) may be performed adjunctively, but unequivocal evidence for its benefits is still lacking. Methods We performed a retrospective single-center study including 192 patients with necrotizing fasciitis or Fournier's gangrene to assess in-hospital mortality and outcome dependent on patient, disease and treatment characteristics with or without HBOT. Results The in-hospital mortality rate was 27.6%. Factors associated with increased mortality according to multivariate analysis were higher age, affection of multiple or problem localizations (odds ratio (OR) = 2.88, P = 0.003), ineligibility for HBOT despite clinical indication (OR = 8.59, P = 0.005), pathogens in blood cultures (OR = 3.36, P = 0.002), complications (OR = 10.35, P |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1749-7922 |
| Relation: | https://doaj.org/toc/1749-7922 |
| DOI: | 10.1186/s13017-022-00448-6 |
| Access URL: | https://doaj.org/article/b9883b919033469e9194bec145f41ff2 |
| Accession Number: | edsdoj.b9883b919033469e9194bec145f41ff2 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 17497922 |
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| DOI: | 10.1186/s13017-022-00448-6 |
| Published in: | World Journal of Emergency Surgery |
| Language: | English |