Academic Journal
Prognostic impact of radiotherapy-induced-lymphopenia in patients treated with breast-conservative surgery
| Title: | Prognostic impact of radiotherapy-induced-lymphopenia in patients treated with breast-conservative surgery |
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| Authors: | Chang Ik Yoon, Jawon Hwang, Dooreh Kim, Jung Hwan Ji, Janghee Lee, Soong June Bae, Joon Jeong, Jee-Suk Chang, Yeona Cho, Hye Sun Lee, Jee Ye Kim, Sung Gwe Ahn |
| Source: | Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023) |
| Publisher Information: | Nature Portfolio, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | Medicine, Science |
| More Details: | Abstract We investigated a prognostic impact of radiotherapy-induced lymphopenia (RIL) in breast cancer patients treated with breast-conservative surgery (BCS). We included 531 breast cancer patients who were treated with BCS and adjuvant radiotherapy. None of these received (neo)adjuvant chemotherapy. Pre- and post- absolute lymphocyte counts (ALC) were reviewed before and after radiotherapy. The primary endpoint was to evaluate recurrence-free survival (RFS) according to the pre-to-post ALC ratio. Binary logistic regression model was used to identify risk factors for RIL. Either continuous or categorical (> 2.4) pre-to-post ALC ratio was associated with RFS. In 531 patients receiving whole breast irradiation (WBI) and regional nodal irradiation (RNI), RFS was significantly reduced in the patients with high pre-to-post ALC ration (> 2.4). In multivariable analysis, low pre-to-post post ALC ratio was significantly related to decreased RFS in the multivariable analysis (HR 2.293, 95% CIs 1.110–4.735, P = 0.025). In 452 patients treated with WBI alone, high pre-to-post ALC ratio was still significantly associated with decreased RFS in the multivariable analysis (HR 2.708, 95% CIs 1.016–7.218, P = 0.046). In binary logistic regression analysis, RNI was only significant risk factor for clinically meaningful RIL. Our findings show that a markedly decrease in ALC during radiotherapy has a negative prognostic impact. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-023-41301-3 |
| Access URL: | https://doaj.org/article/b9250800fb08420fa142b5e688a5dbe8 |
| Accession Number: | edsdoj.b9250800fb08420fa142b5e688a5dbe8 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20452322 |
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| DOI: | 10.1038/s41598-023-41301-3 |
| Published in: | Scientific Reports |
| Language: | English |