Bibliographic Details
| Title: |
Low Eosinophil Phenotype Predicts Noninvasive Mechanical Ventilation Use in Patients with Hospitalized Exacerbations of COPD |
| Authors: |
Wei T, Wang X, Lang K, Chen C, Song Y, Luo J, Gu Z, Hu X, Yang D |
| Source: |
Journal of Inflammation Research, Vol Volume 15, Pp 1259-1271 (2022) |
| Publisher Information: |
Dove Medical Press, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Pathology
LCC:Therapeutics. Pharmacology |
| Subject Terms: |
chronic obstructive pulmonary disease, acute exacerbation, eosinophilic inflammation, prognostic phenotype, noninvasive mechanical ventilation, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950 |
| More Details: |
Tingting Wei,* Xiaocen Wang,* Ke Lang,* Cuicui Chen, Yansha Song, Jinlong Luo, Zhaolin Gu, Xianglin Hu, Dong Yang Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dong Yang; Xianglin Hu, Email yang.dong@zs-hospital.sh.cn; xianglinhero@163.comRationale: Eosinophilic inflammation is related to the progression and outcomes of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Till now, few studies have focused on low EOS in AECOPD.Objective: To reveal the clinical characteristics, therapeutic responses and prognosis of patients hospitalized of AECOPD with low EOS.Methods: The electronic database of Zhongshan Hospital, Fudan University was used. Cohort 1 included 608 patients with hospitalized AECOPD. Study population 2 consisted of 166 patients with AECOPD admission at least twice. Impact of low EOS on NIMV treatment, length of hospital stays and 12-month AECOPD-related readmission were analyzed with multivariable logistic regression model. Thirty-five hospitalized AECOPD patients were prospectively recruited as cohort 3 to explore the association between EOS and other immune cells using Spearman correlation coefficient for ranked data.Results: EOS level was suppressed on admission in AECOPD patients, and significantly improved after hospitalized treatment (P < 0.05). For inflammatory markers, leucocytes, neutrophils and lactate dehydrogenase levels were higher, while lymphocytes, monocytes and interleukin-6 levels were lower in the low-EOS group than those in the non-low EOS group (P < 0.05). Low EOS (EOS < 50 cells/μL) was an independent risk factor of NIMV use (OR = 1.86, 95% CI = 1.26 ∼ 2.73). The EOS percentage was positively correlated with the T cell percentage (r = 0.46, P < 0.05) and negatively correlated with the natural killer cell percentage (r = − 0.39, P < 0.05). The patients with low EOS had lower level of CD4+ T cell (P < 0.05) than that of patients with non-low EOS.Conclusion: Low EOS might be a stable phenotype in patients with hospitalized AECOPD and could be used to inform NIMV management, hyperinflammatory state and impaired immunity situation.Keywords: chronic obstructive pulmonary disease, acute exacerbation, eosinophilic inflammation, prognostic phenotype, noninvasive mechanical ventilation |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1178-7031 |
| Relation: |
https://www.dovepress.com/low-eosinophil-phenotype-predicts-noninvasive-mechanical-ventilation-u-peer-reviewed-fulltext-article-JIR; https://doaj.org/toc/1178-7031 |
| Access URL: |
https://doaj.org/article/db8fc2db537d4edebf379b368ddfe6c4 |
| Accession Number: |
edsdoj.b8fc2db537d4edebf379b368ddfe6c4 |
| Database: |
Directory of Open Access Journals |
