Academic Journal
Osteointegration of functionalised high-performance oxide ceramics: imaging from micro-computed tomography
| Title: | Osteointegration of functionalised high-performance oxide ceramics: imaging from micro-computed tomography |
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| Authors: | Filippo Migliorini, Jörg Eschweiler, Marcel Betsch, Nicola Maffulli, Markus Tingart, Frank Hildebrand, Sophie Lecouturier, Björn Rath, Hanno Schenker |
| Source: | Journal of Orthopaedic Surgery and Research, Vol 19, Iss 1, Pp 1-8 (2024) |
| Publisher Information: | BMC, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Orthopedic surgery LCC:Diseases of the musculoskeletal system |
| Subject Terms: | Ossification, Implants, Osteointegration, Micro-CT, Orthopedic surgery, RD701-811, Diseases of the musculoskeletal system, RC925-935 |
| More Details: | Abstract Background This study evaluated the osseointegration potential of functionalised high-performance oxide ceramics (HPOC) in isolation or coated with BMP-2 or RGD peptides in 36 New Zeeland female rabbits using micro-computed tomography (micro CT). The primary outcomes of interest were to assess the amount of ossification evaluating the improvement in the bone volume/ total volume (BV/TV) ratio and trabecular thickness at 6 and 12 weeks. The second outcome of interest was to investigate possible differences in osteointegration between the functionalised silanised HPOC in isolation or coated with Bone Morphogenetic Protein 2 (BMP-2) or RGD peptides. Methods 36 adult female New Zealand white rabbits with a minimum weight of three kg were used. One-third of HPOCs were functionalised with silicon suboxide (SiOx), a third with BMP-2 (sHPOC-BMP2), and another third with RGD (sHPOC-RGD). All samples were scanned with a high-resolution micro CT (U-CTHR, MILabs B.V., Houten, The Netherlands) with a reconstructed voxel resolution of 10 µm. MicroCT scans were reconstructed in three planes and processed using Imalytics Preclinical version 2.1 (Gremse-IT GmbH, Aachen, Germany) software. The total volume (TV), bone volume (BV) and ratio BV/TV were calculated within the coating area. Results BV/TV increased significantly from 6 to 12 weeks in all HPOCs: silanised (P = 0.01), BMP-2 (P |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1749-799X |
| Relation: | https://doaj.org/toc/1749-799X |
| DOI: | 10.1186/s13018-024-04918-2 |
| Access URL: | https://doaj.org/article/b8e4c7afa7974f8a91d2dddc82a8f7a1 |
| Accession Number: | edsdoj.b8e4c7afa7974f8a91d2dddc82a8f7a1 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 1749799X |
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| DOI: | 10.1186/s13018-024-04918-2 |
| Published in: | Journal of Orthopaedic Surgery and Research |
| Language: | English |