Bibliographic Details
| Title: |
Elevated sortilin expression discriminates functional from non-functional neuroendocrine tumors and enables therapeutic targeting |
| Authors: |
Felix Bolduan, Alexandra Wetzel, Yvonne Giesecke, Ines Eichhorn, Natalia Alenina, Michael Bader, Thomas E. Willnow, Bertram Wiedenmann, Michael Sigal |
| Source: |
Frontiers in Endocrinology, Vol 15 (2024) |
| Publisher Information: |
Frontiers Media S.A., 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: |
neuroendocrine tumors, functional syndrome, carcinoid syndrome, serotonin, sortilin, organoids, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: |
A subset of neuroendocrine tumors (NETs) can cause an excessive secretion of hormones, neuropeptides, and biogenic amines into the bloodstream. These so-called functional NETs evoke a hormone-related disease and lead to several different syndromes, depending on the factors released. One of the most common functional syndromes, carcinoid syndrome, is characterized mainly by over-secretion of serotonin. However, what distinguishes functional from non-functional tumors on a molecular level remains unknown. Here, we demonstrate that the expression of sortilin, a widely expressed transmembrane receptor involved in intracellular protein sorting, is significantly increased in functional compared to non-functional NETs and thus can be used as a biomarker for functional NETs. Furthermore, using a cell line model of functional NETs, as well as organoids, we demonstrate that inhibition of sortilin reduces cellular serotonin concentrations and may therefore serve as a novel therapeutic target to treat patients with carcinoid syndrome. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-2392 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fendo.2024.1331231/full; https://doaj.org/toc/1664-2392 |
| DOI: |
10.3389/fendo.2024.1331231 |
| Access URL: |
https://doaj.org/article/b881f1739a044e80897f6303970ea413 |
| Accession Number: |
edsdoj.b881f1739a044e80897f6303970ea413 |
| Database: |
Directory of Open Access Journals |
