Preparation and Characterization of Biocompatible Iron/Zirconium/Polydopamine/Carboxymethyl Chitosan Hydrogel with Fenton Catalytic Properties and Photothermal Efficacy

Bibliographic Details
Title: Preparation and Characterization of Biocompatible Iron/Zirconium/Polydopamine/Carboxymethyl Chitosan Hydrogel with Fenton Catalytic Properties and Photothermal Efficacy
Authors: Xiaoyi Zheng, Hang Wu, Shige Wang, Jiulong Zhao, Lianghao Hu
Source: Gels, Vol 9, Iss 6, p 452 (2023)
Publisher Information: MDPI AG, 2023.
Publication Year: 2023
Collection: LCC:Science
LCC:Chemistry
LCC:Inorganic chemistry
LCC:General. Including alchemy
Subject Terms: hydrogel, photothermal therapy, chemodynamic therapy, Fenton reaction, Science, Chemistry, QD1-999, Inorganic chemistry, QD146-197, General. Including alchemy, QD1-65
More Details: In recent years, multifunctional hydrogel nanoplatforms for the synergistic treatment of tumors have received a great deal of attention. Here, we prepared an iron/zirconium/polydopamine/carboxymethyl chitosan hydrogel with Fenton and photothermal effects, promising for future use in the field of synergistic therapy and prevention of tumor recurrence. The iron (Fe)–zirconium (Zr)@ polydopamine (PDA) nanoparticles were synthesized by a simple one-pot hydrothermal method using iron (III) chloride hexahydrate (FeCl3•6H2O), zirconium tetrachloride (ZrCl4), and dopamine, followed by activation of the carboxyl group of carboxymethyl chitosan (CMCS) using 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC)/N(4)-hydroxycytidine (NHS). Finally, the Fe–Zr@PDA nanoparticles and the activated CMCS were mixed to form a hydrogel. On the one side, Fe ions can use hydrogen peroxide (H2O2) which is rich in the tumor microenvironment (TME) to produce toxic hydroxyl radicals (•OH) and kill tumor cells, and Zr can also enhance the Fenton effect; on the other side, the excellent photothermal conversion efficiency of the incorporated PDA is used to kill tumor cells under the irradiation of near-infrared light. The ability of Fe–Zr@PDA@CMCS hydrogel to produce •OH and the ability of photothermal conversion were verified in vitro, and swelling and degradation experiments confirmed the effective release and good degradation of this hydrogel in an acidic environment. The multifunctional hydrogel is biologically safe at both cellular and animal levels. Therefore, this hydrogel has a wide range of applications in the synergistic treatment of tumors and the prevention of recurrence.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2310-2861
Relation: https://www.mdpi.com/2310-2861/9/6/452; https://doaj.org/toc/2310-2861
DOI: 10.3390/gels9060452
Access URL: https://doaj.org/article/b84f587f59524c6db6097e061de29881
Accession Number: edsdoj.b84f587f59524c6db6097e061de29881
Database: Directory of Open Access Journals
More Details
ISSN:23102861
DOI:10.3390/gels9060452
Published in:Gels
Language:English