| Title: |
Transforming a Targeted Porphyrin Theranostic Agent into a PET Imaging Probe for Cancer |
| Authors: |
Jiyun Shi, Tracy W.B. Liu, Juan Chen, David Green, David Jaffray, Brian C. Wilson, Fan Wang, Gang Zheng |
| Source: |
Theranostics, Vol 1, Iss 1, Pp 363-370 (2011) |
| Publisher Information: |
Ivyspring International Publisher, 2011. |
| Publication Year: |
2011 |
| Collection: |
LCC:Medicine |
| Subject Terms: |
Medicine |
| More Details: |
Porphyrin based photosensitizers are useful agents for photodynamic therapy (PDT) and fluorescence imaging of cancer. Porphyrins are also excellent metal chelators forming highly stable metallo-complexes making them efficient delivery vehicles for radioisotopes. Here we investigated the possibility of incorporating 64Cu into a porphyrin-peptide-folate (PPF) probe developed previously as folate receptor (FR) targeted fluorescent/PDT agent, and evaluated the potential of turning the resulting 64Cu-PPF into a positron emission tomography (PET) probe for cancer imaging. Noninvasive PET imaging followed by radioassay evaluated the tumor accumulation, pharmacokinetics and biodistribution of 64Cu-PPF. 64Cu-PPF uptake in FR-positive tumors was visible on small-animal PET images with high tumor-to-muscle ratio (8.88 ± 3.60) observed after 24 h. Competitive blocking studies confirmed the FR-mediated tracer uptake by the tumor. The ease of efficient 64Cu-radiolabeling of PPF while retaining its favorable biodistribution, pharmacokinetics and selective tumor uptake, provides a robust strategy to transform tumor-targeted porphyrin-based photosensitizers into PET imaging probes. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1838-7640 |
| Relation: |
http://www.thno.org/v01p0363.htm; https://doaj.org/toc/1838-7640 |
| Access URL: |
https://doaj.org/article/b8390c29229e4cab8ed7fc7ea39ffcbb |
| Accession Number: |
edsdoj.b8390c29229e4cab8ed7fc7ea39ffcbb |
| Database: |
Directory of Open Access Journals |
