Bibliographic Details
| Title: |
Postural Instability and Risk of Falls in Patients with Parkinson’s Disease Treated with Deep Brain Stimulation: A Stabilometric Platform Study |
| Authors: |
Giorgio Leodori, Marco Santilli, Nicola Modugno, Michele D’Avino, Maria Ilenia De Bartolo, Andrea Fabbrini, Lorenzo Rocchi, Antonella Conte, Giovanni Fabbrini, Daniele Belvisi |
| Source: |
Brain Sciences, Vol 13, Iss 9, p 1243 (2023) |
| Publisher Information: |
MDPI AG, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Subject Terms: |
deep brain stimulation, fall risk, falls, Parkinson’s disease, postural instability, stabilometric platform, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| More Details: |
Postural instability (PI) in Parkinson’s disease (PD) exposes patients to an increased risk of falls (RF). While dopaminergic therapy and deep brain stimulation (DBS) improve motor performance in advanced PD patients, their effects on PI and RF remain elusive. PI and RF were assessed using a stabilometric platform in six advanced PD patients. Patients were evaluated in OFF and ON dopaminergic medication and under four DBS settings: with DBS off, DBS bilateral, and unilateral DBS of the more- or less-affected side. Our findings indicate that dopaminergic medication by itself exacerbated PI and RF, and DBS alone led to a decline in RF. No combination of medication and DBS yielded a superior improvement in postural control compared to the baseline combination of OFF medication and the DBS-off condition. Yet, for ON medication, DBS significantly improved both PI and RF. Among DBS conditions, DBS bilateral provided the most favorable outcomes, improving PI and RF in the ON medication state and presenting the smallest setbacks in the OFF state. Conversely, the more-affected side DBS was less beneficial. These preliminary results could inform therapeutic strategies for advanced PD patients experiencing postural disorders. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2076-3425 |
| Relation: |
https://www.mdpi.com/2076-3425/13/9/1243; https://doaj.org/toc/2076-3425 |
| DOI: |
10.3390/brainsci13091243 |
| Access URL: |
https://doaj.org/article/eb7f6f8583314487aea2e86d595b99f8 |
| Accession Number: |
edsdoj.b7f6f8583314487aea2e86d595b99f8 |
| Database: |
Directory of Open Access Journals |
|
Full text is not displayed to guests. |
Login for full access.
|
