Autochthonous Leishmaniasis Caused by Leishmania tropica, Identified by Using Whole-Genome Sequencing, Sri Lanka
| Title: | Autochthonous Leishmaniasis Caused by Leishmania tropica, Identified by Using Whole-Genome Sequencing, Sri Lanka |
|---|---|
| Authors: | Hermali Silva, Tiago R. Ferreira, Kajan Muneeswaran, Sumudu R. Samarasinghe, Eliza V.C. Alves-Ferreira, Michael E. Grigg, Naduviladath V. Chandrasekharan, David L. Sacks, Nadira D. Karunaweera |
| Source: | Emerging Infectious Diseases, Vol 30, Iss 9, Pp 1872-1883 (2024) |
| Publisher Information: | Centers for Disease Control and Prevention, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medicine LCC:Infectious and parasitic diseases |
| Subject Terms: | Leishmania tropica, Leishmania donovani, leishmaniasis, autochthonous, cutaneous, mucocutaneous, Medicine, Infectious and parasitic diseases, RC109-216 |
| More Details: | Cutaneous leishmaniasis is atypical in Sri Lanka because Leishmania donovani, which typically causes visceral disease, is the causative agent. The origins of recently described hybrids between L. donovani and other Leishmania spp. usually responsible for cutaneous leishmaniasis remain unknown. Other endemic dermotropic Leishmania spp. have not been reported in Sri Lanka. Genome analysis of 27 clinical isolates from Sri Lanka and 32 Old World Leishmania spp. strains found 8 patient isolates clustered with L. tropica and 19 with L. donovani. The L. tropica isolates from Sri Lanka shared markers with strain LtK26 reported decades ago in India, indicating they were not products of recent interspecies hybridization. Because L. tropica was isolated from patients with leishmaniasis in Sri Lanka, our findings indicate L. donovani is not the only cause of cutaneous leishmaniasis in Sri Lanka and potentially explains a haplotype that led to interspecies dermotropic L. donovani hybrids. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1080-6040 1080-6059 |
| Relation: | https://wwwnc.cdc.gov/eid/article/30/9/23-1238_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059 |
| DOI: | 10.3201/eid3009.231238 |
| Access URL: | https://doaj.org/article/b7cf2eb01d60490dbf5eba817945b4b6 |
| Accession Number: | edsdoj.b7cf2eb01d60490dbf5eba817945b4b6 |
| Database: | Directory of Open Access Journals |
| ISSN: | 10806040 10806059 |
|---|---|
| DOI: | 10.3201/eid3009.231238 |
| Published in: | Emerging Infectious Diseases |
| Language: | English |