Bibliographic Details
| Title: |
Leukocyte telomere length-related rs621559 and rs398652 genetic variants influence risk of HBV-related hepatocellular carcinoma. |
| Authors: |
Wenting Pan, Guangxia Cheng, Huaixin Xing, Juan Shi, Chao Lu, Jinyu Wei, Lichao Li, Changchun Zhou, Qipeng Yuan, Liqing Zhou, Ming Yang |
| Source: |
PLoS ONE, Vol 9, Iss 11, p e110863 (2014) |
| Publisher Information: |
Public Library of Science (PLoS), 2014. |
| Publication Year: |
2014 |
| Collection: |
LCC:Medicine
LCC:Science |
| Subject Terms: |
Medicine, Science |
| More Details: |
Recent genome-wide association studies (GWAS) have identified eleven leukocyte telomere length (LTL)-related single nucleotide polymorphisms (SNPs). Since LTL has been associated with risk of many malignancies, LTL-related SNPs may contribute to cancer susceptibility. To test this hypothesis in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), we genotyped these eleven LTL-related SNPs in a case-control set including 1186 HBV-related HCC cases, 508 chronic HBV carriers and 1308 healthy controls at the discovery stage. The associations of HCC risk with these SNPs were further confirmed in an independent case-control set. We found that 1p34.2 rs621559 and 14q21 rs398652 were significantly associated with HBV-related HCC risk (both P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1932-6203 |
| Relation: |
http://europepmc.org/articles/PMC4218833?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: |
10.1371/journal.pone.0110863 |
| Access URL: |
https://doaj.org/article/b724165ade79402cadd1981a681420e5 |
| Accession Number: |
edsdoj.b724165ade79402cadd1981a681420e5 |
| Database: |
Directory of Open Access Journals |
