Bibliographic Details
| Title: |
Comparison between diffusion-weighted magnetic resonance and positron-emission tomography in the evaluation of treated lymphomas with mediastinal involvement |
| Authors: |
Francesca Di Giuliano, Eliseo Picchi, Noemi Pucci, Silvia Minosse, Valentina Ferrazzoli, Giulia Pizzicannella, Cecilia Angeloni, Daniela Nasso, Agostino Chiaravalloti, Francesco Garaci, Roberto Floris |
| Source: |
The Egyptian Journal of Radiology and Nuclear Medicine, Vol 53, Iss 1, Pp 1-9 (2022) |
| Publisher Information: |
SpringerOpen, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Medical physics. Medical radiology. Nuclear medicine |
| Subject Terms: |
Mediastinal lymphoma, Response assessment, Magnetic resonance imaging, DWIBS, 18F-FDG PET/CT, Medical physics. Medical radiology. Nuclear medicine, R895-920 |
| More Details: |
Abstract Background The persistence of residual tissue after treatment is frequent in patients with mediastinal lymphomas and it is often characterized by 18F-Flurodeoxyglucose Positron Emission Tomography (18F-FDG PET) uptake. This study aims to investigate the usefulness of diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) sequence in residual tissues of treated mediastinal lymphomas and to compare it with 18F-FDG PET-CT. Results We included 21 patients with mediastinal Hodgkin and non-Hodgkin lymphomas who showed residual masses on PET-CT imaging at end of treatment and underwent DWIBS-Magnetic Resonance Imaging (MRI). SUVmax and Apparent Diffusion Coefficient (ADC) values of residual masses were assessed quantitatively, including measurement of mean ADC. 15 patients showed radiotracer uptake at 18F-FDG PET-CT, among them only 3 had positive DWIBS-MRI with low ADC values (median value: 0.90 mm2/s). The mediastinal biopsy in these 3 “double positive” patients confirmed pathological residual tissue. All the patients with positive 18F-FDG PET-CT but negative DWIBS-MRI (n = 18) with high ADC values (median value: 2.05 mm2/s) were confirmed negative by biopsy. Conclusions DWIBS-MRI examination combined with ADC measurement allowed to discriminate pathological and non-pathological residual tissue in patients with treated mediastinal lymphoma. These preliminary results seem to pave the way for a leading role of the MRI which could be a useful alternative to the 18F-FDG PET/CT. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2090-4762 |
| Relation: |
https://doaj.org/toc/2090-4762 |
| DOI: |
10.1186/s43055-022-00825-w |
| Access URL: |
https://doaj.org/article/b6ec0198c89a4e17b6bcd161068e0cfe |
| Accession Number: |
edsdoj.b6ec0198c89a4e17b6bcd161068e0cfe |
| Database: |
Directory of Open Access Journals |
