The Role and Mechanism of Probiotics Supplementation in Blood Glucose Regulation: A Review
| Title: | The Role and Mechanism of Probiotics Supplementation in Blood Glucose Regulation: A Review |
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| Authors: | Xinyu Shen, Chunmin Ma, Yang Yang, Xiaofei Liu, Bing Wang, Yan Wang, Guang Zhang, Xin Bian, Na Zhang |
| Source: | Foods, Vol 13, Iss 17, p 2719 (2024) |
| Publisher Information: | MDPI AG, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Chemical technology |
| Subject Terms: | probiotics, blood glucose regulation, type 2 diabetes mellitus, gut microbiota, insulin resistance, intestinal flora, Chemical technology, TP1-1185 |
| More Details: | With economic growth and improved living standards, the incidence of metabolic diseases such as diabetes mellitus caused by over-nutrition has risen sharply worldwide. Elevated blood glucose and complications in patients seriously affect the quality of life and increase the economic burden. There are limitations and side effects of current hypoglycemic drugs, while probiotics, which are safe, economical, and effective, have good application prospects in disease prevention and remodeling of intestinal microecological health and are gradually becoming a research hotspot for diabetes prevention and treatment, capable of lowering blood glucose and alleviating complications, among other things. Probiotic supplementation is a microbiologically based approach to the treatment of type 2 diabetes mellitus (T2DM), which can achieve anti-diabetic efficacy through the regulation of different tissues and metabolic pathways. In this study, we summarize recent findings that probiotic intake can achieve blood glucose regulation by modulating intestinal flora, decreasing chronic low-grade inflammation, modulating glucagon-like peptide-1 (GLP-1), decreasing oxidative stress, ameliorating insulin resistance, and increasing short-chain fatty acids (SCFAs) content. Moreover, the mechanism, application, development prospect, and challenges of probiotics regulating blood glucose were discussed to provide theoretical references and a guiding basis for the development of probiotic preparations and related functional foods regulating blood glucose. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 13172719 2304-8158 |
| Relation: | https://www.mdpi.com/2304-8158/13/17/2719; https://doaj.org/toc/2304-8158 |
| DOI: | 10.3390/foods13172719 |
| Access URL: | https://doaj.org/article/cb683ba735344453ae095ef4fc516b52 |
| Accession Number: | edsdoj.b683ba735344453ae095ef4fc516b52 |
| Database: | Directory of Open Access Journals |
| ISSN: | 13172719 23048158 |
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| DOI: | 10.3390/foods13172719 |
| Published in: | Foods |
| Language: | English |