Academic Journal
Rare entities in head-and-neck cancer: salvage re-irradiation with carbon ions
| Title: | Rare entities in head-and-neck cancer: salvage re-irradiation with carbon ions |
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| Authors: | Thomas Held, Paul Windisch, Sati Akbaba, Kristin Lang, Benjamin Farnia, Jakob Liermann, Denise Bernhardt, Peter Plinkert, Christian Freudlsperger, Stefan Rieken, Klaus Herfarth, Jürgen Debus, Sebastian Adeberg |
| Source: | Radiation Oncology, Vol 14, Iss 1, Pp 1-7 (2019) |
| Publisher Information: | BMC, 2019. |
| Publication Year: | 2019 |
| Collection: | LCC:Medical physics. Medical radiology. Nuclear medicine LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: | Salvage re-irradiation, Head and neck cancer, Carbon ions, Mucoepidermoid carcinoma, Particle therapy, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: | Abstract Background The objective of this investigation is to evaluate the outcomes and toxicity of carbon-ion re-irradiation (CIR) in patients with rare head and neck cancers (HNC). There is a paucity of data regarding treatment approaches in this patient cohort, which we aim to address in this work. Methods Thirty-two (n = 32) consecutive patients with uncommon HNC treated between 2010 and 2017 were retrospectively analyzed in terms of clinical outcomes, patterns of failure, and toxicity. Results Mucoepidermoid carcinoma (MEC) was the most common histology (22%). Patients received a median cumulative dose equivalent in 2 Gy fractions (EQD2) after CIR of 128.6 Gy (range, 105.8–146.5 Gy). The local and distant control rates 1 year after CIR were 66 and 72%. No serious acute or late toxicity (≥ grade 3) after CIR was observed. Conclusions CIR may represent an effective and safe treatment alternative to palliative systemic therapies in these rare indications. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1748-717X |
| Relation: | http://link.springer.com/article/10.1186/s13014-019-1406-x; https://doaj.org/toc/1748-717X |
| DOI: | 10.1186/s13014-019-1406-x |
| Access URL: | https://doaj.org/article/b5f90db4cb2b4356afc32bf2f2d039e2 |
| Accession Number: | edsdoj.b5f90db4cb2b4356afc32bf2f2d039e2 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 1748717X |
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| DOI: | 10.1186/s13014-019-1406-x |
| Published in: | Radiation Oncology |
| Language: | English |