| Title: |
Surgery versus radiotherapy in octogenarians with stage Ia non‑small cell lung cancer: propensity score matching analysis of the SEER database |
| Authors: |
Lianfang Ni, Gang Lin, Zhigang Zhang, Dan Sun, Zhonghui Liu, Xinmin Liu |
| Source: |
BMC Pulmonary Medicine, Vol 22, Iss 1, Pp 1-10 (2022) |
| Publisher Information: |
BMC, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Diseases of the respiratory system |
| Subject Terms: |
NSCLC, Octogenarian, Surgery, Radiotherapy, SEER, Diseases of the respiratory system, RC705-779 |
| More Details: |
Abstract Objectives To compare overall survival (OS) and cancer-specific survival (CSS) outcomes of surgery with radiotherapy in octogenarians with stage Ia non-small cell lung cancer (NSCLC). Materials and methods Patients aged ≥ 80 years with clinical stage Ia (T1N0M0) NSCLC between 2012 and 2017 were identified from the population-based Surveillance, Epidemiology, and End Results (SEER) database. Patients were assigned into surgery and radiotherapy groups. Multivariate Cox regression analysis was used to identify survival-associated factors. Treatment groups were adjusted by propensity score matching (PSM) analysis while OS and CSS outcomes were compared among groups by Kaplan–Meier analysis. Results A total of 1641 patients were identified, with 46.0% in the surgical group and 54.0% in the radiotherapy group. Compared to surgery, radiotherapy-treated patients were older, later diagnosed, had more often unmarried, more squamous cell carcinoma, more unknown grade and increased tumor sizes. Radiotherapy was associated with a significantly worse OS, compared to surgery (hazard ratio 2.426; 95% CI 2.003–2.939; P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1471-2466 |
| Relation: |
https://doaj.org/toc/1471-2466 |
| DOI: |
10.1186/s12890-022-02177-7 |
| Access URL: |
https://doaj.org/article/ab5adf8bb1ca49bd974a9850ed9bcd6c |
| Accession Number: |
edsdoj.b5adf8bb1ca49bd974a9850ed9bcd6c |
| Database: |
Directory of Open Access Journals |
