Bibliographic Details
| Title: |
The Association between the Body Mass Index, Chronic Obstructive Pulmonary Disease and SUV of the Non-Tumorous Lung in the Pretreatment [18F]FDG-PET/CT of Patients with Lung Cancer |
| Authors: |
Lukas Wehlte, Julia Walter, Lea Daisenberger, Felix Kuhnle, Maria Ingenerf, Christine Schmid-Tannwald, Matthias Brendel, Diego Kauffmann-Guerrero, Lucie Heinzerling, Amanda Tufman, Thomas Pfluger, Friederike Völter |
| Source: |
Diagnostics, Vol 14, Iss 11, p 1139 (2024) |
| Publisher Information: |
MDPI AG, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Medicine (General) |
| Subject Terms: |
lung cancer, NSCLC, SCLC, PET, PET/CT, SUV, Medicine (General), R5-920 |
| More Details: |
Background: A debate persists on the prognostic value of the pre-therapeutic standardized uptake value (SUV) of non-tumorous lung tissue for the risk assessment of therapy-related pneumonitis, with most studies lacking significant correlation. However, the influence of patient comorbidities on the pre-therapeutic lung SUV has not yet been systematically evaluated. Thus, we aimed to elucidate the association between comorbidities, biological variables and lung SUVs in pre-therapeutic [18F]FDG-PET/CT. Methods: In this retrospective study, the pre-therapeutic SUV in [18F]FDG-PET/CT was measured in non-tumorous areas of both lobes of the lung. SUVMEAN, SUVMAX and SUV95 were compared to a multitude of patient characteristics and comorbidities with Spearman’s correlation analysis, followed by a Bonferroni correction and multilinear regression. Results: In total, 240 patients with lung cancer were analyzed. An elevated BMI was significantly associated with increased SUVMAX (β = 0.037, p < 0.001), SUVMEAN (β = 0.017, p < 0.001) and SUV95 (β = 0.028, p < 0.001). Patients with chronic obstructive pulmonary disease (COPD) showed a significantly decreased SUVMAX (β = −0.156, p = 0.001), SUVMEAN (β = −0.107, p < 0.001) and SUV95 (β = −0.134, p < 0.001). Multiple other comorbidities did not show a significant correlation with the SUV of the non-tumorous lung. Conclusions: Failure to consider the influence of BMI and COPD on the pre-therapeutic SUV measurements may lead to an erroneous interpretation of the pre-therapeutic SUV and subsequent treatment decisions in patients with lung cancer. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2075-4418 |
| Relation: |
https://www.mdpi.com/2075-4418/14/11/1139; https://doaj.org/toc/2075-4418 |
| DOI: |
10.3390/diagnostics14111139 |
| Access URL: |
https://doaj.org/article/b5762d8df97f407c91d6c5083b1b3595 |
| Accession Number: |
edsdoj.b5762d8df97f407c91d6c5083b1b3595 |
| Database: |
Directory of Open Access Journals |
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