Bibliographic Details
| Title: |
Synthesis, characterization, and therapeutic applications of LAP/PDA composite nanomaterials in silk fibroin-based hydrogels for enhanced neuroregeneration in stroke |
| Authors: |
Huiyuan Peng, Weihua Guo, Jinsong Wang, Weili Xia, Yu Xiong, Wenhua Xu, Weibo Dai, Feng Zheng |
| Source: |
Alexandria Engineering Journal, Vol 91, Iss , Pp 648-657 (2024) |
| Publisher Information: |
Elsevier, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Engineering (General). Civil engineering (General) |
| Subject Terms: |
Stroke, LAP/PDA composite nanomaterials, Silk fibroin hydrogels, Human mesenchymal stem cells, Brain-derived neurotrophic factor, Neuroregeneration, Engineering (General). Civil engineering (General), TA1-2040 |
| More Details: |
Addressing the devastating and often irreversible effects of stroke necessitates innovative therapeutic strategies that go beyond the limitations of current treatments. This study heralds a promising interdisciplinary approach by employing LAP/PDA composite nanomaterials integrated into silk fibroin-based hydrogels. These engineered materials not only demonstrated significantly enhanced mechanical properties, but also showed excellent biocompatibility when co-cultured with human mesenchymal stem cells (hMSCs). Importantly, the application of these composite hydrogels in stroke models yielded remarkable therapeutic outcomes. The results indicated a substantial reduction in cerebral infarction volumes, improved survival rates of transplanted hMSCs, and increased neurogenesis, underlining their transformative potential in stroke management. Molecular markers such as AQP4, α-DG, and β-DG were also explored, revealing modulated astrocyte activation and cellular signaling pathways. In summary, the composite LAP/PDA nanomaterials, in conjunction with hMSCs and Brain-Derived Neurotrophic Factor (BDNF), unveil a compelling and multifaceted approach for addressing the unmet needs in stroke treatment, thereby opening new avenues in regenerative medicine and tissue engineering. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1110-0168 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1110016824001674; https://doaj.org/toc/1110-0168 |
| DOI: |
10.1016/j.aej.2024.02.028 |
| Access URL: |
https://doaj.org/article/b56885302744448abfa1fe0a5e962ae9 |
| Accession Number: |
edsdoj.b56885302744448abfa1fe0a5e962ae9 |
| Database: |
Directory of Open Access Journals |
