Academic Journal
The prevalence of latent tuberculosis infection in patients with chronic kidney disease: A systematic review and meta-analysis
| Title: | The prevalence of latent tuberculosis infection in patients with chronic kidney disease: A systematic review and meta-analysis |
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| Authors: | Ayinalem Alemu, Zebenay Workneh Bitew, Getu Diriba, Getachew Seid, Shewki Moga, Saro Abdella, Emebet Gashu, Kirubel Eshetu, Getachew Tollera, Mesay Hailu Dangisso, Balako Gumi |
| Source: | Heliyon, Vol 9, Iss 6, Pp e17181- (2023) |
| Publisher Information: | Elsevier, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Science (General) LCC:Social sciences (General) |
| Subject Terms: | Latent tuberculosis, Chronic kidney disease, Dialysis, Hemodialysis, Renal transplant, Peritoneal dialysis, Science (General), Q1-390, Social sciences (General), H1-99 |
| More Details: | Objective: To estimate the prevalence of latent tuberculosis infection (LTBI) in chronic kidney disease (CKD) patients. Methods: This study was conducted following the PRISMA guidelines. We identified, 3694 studies from the whole search, and 59 studies were included. Each study's quality was assessed using JBI checklist. We employed STATA version 17 for statistical analysis. We assessed heterogeneity using I2 heterogeneity test. Publication bias was assessed using funnel plot and Egger's test. We estimated the pooled LTBI prevalence in CKD patients along with 95%CI. Results: The pooled prevalence of LTBI among CKD patients using data collected from 53 studies having 12,772 patients was 30.2% (95%CI; 25.5, 34.8). The pooled prevalence among pre-dialysis, hemodialysis, peritoneal dialysis, and renal transplanted patients was 17.8% (95%CI; 3.3, 32.4), 34.8% (95%CI; 29.1, 40.5), 25% (95%CI; 11, 38), and 16% (95%CI; 7, 25), respectively. The pooled prevalence of LTBI stratified by the laboratory screening methods was 25.3% (95%CI: 20.3–30.3) using TST, 28.0% (95%CI; 23.9–32.0) using QFT, and 32.6%, (95%CI: 23.7–41.5) using T-SPOT. Conclusion: There is high prevalence of LTBI among CKD patients mainly in patients on dialysis. Thus, early diagnosis and treatment of LTBI in CKD patients should be performed to prevent active TB in CKD patients.PROSPERO registration number: CRD42022372441. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S240584402304389X; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2023.e17181 |
| Access URL: | https://doaj.org/article/b5215c5d062542a489081a0dce8e1a1f |
| Accession Number: | edsdoj.b5215c5d062542a489081a0dce8e1a1f |
| Database: | Directory of Open Access Journals |
| ISSN: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2023.e17181 |
| Published in: | Heliyon |
| Language: | English |