Academic Journal
Changes of biochemical factors and the effect on recurrence of medullary thyroid carcinoma after surgery
| Title: | Changes of biochemical factors and the effect on recurrence of medullary thyroid carcinoma after surgery |
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| Authors: | Fengli Guo, Lijuan Li, Pengfei Gu, Guoqiang Zhang, Xianhui Ruan, Jingzhu Zhao, Xiangqian Zheng, Songfeng Wei, Ming Gao |
| Source: | Heliyon, Vol 10, Iss 8, Pp e29857- (2024) |
| Publisher Information: | Elsevier, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Science (General) LCC:Social sciences (General) |
| Subject Terms: | Medullary thyroid carcinoma, Calcitonin, Normalization of calcitonin, Biochemical cure, Disease-free survival, Science (General), Q1-390, Social sciences (General), H1-99 |
| More Details: | Objective: Medullary thyroid carcinoma (MTC) is a rare malignancy secreting calcitonin (Ctn). We aimed to analyze the relationship between Ctn levels at different time points in patients with MTC, and evaluate its predictive effect on recurrence. Methods: A retrospective study of patients diagnosed with MTC in a large medical center were conducted in northern China. The interrelationships between preoperative Ctn, normalization of postoperative serum Ctn at the first month (NPS), and long-term biochemical cure as well as their predicting roles on structural recurrence were assessed. Results: A total of 212 patients were included in this study. The median follow-up time was 59.5 months. The 5- and 10-year cumulative disease-free survival rates were 81.5 % and 66.8 %, respectively. NPS (OR: 216.33, 95 % CI: 28.69–1631.09, P |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844024058882; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2024.e29857 |
| Access URL: | https://doaj.org/article/b51dc9c72f694948a04cfdb07c1a2dfd |
| Accession Number: | edsdoj.b51dc9c72f694948a04cfdb07c1a2dfd |
| Database: | Directory of Open Access Journals |
| ISSN: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2024.e29857 |
| Published in: | Heliyon |
| Language: | English |