Intra-tumor heterogeneity for endometrial cancer and its clinical significance
| Title: | Intra-tumor heterogeneity for endometrial cancer and its clinical significance |
|---|---|
| Authors: | Fu-Fen Yin, Li-Jun Zhao, Xiao-Yu Ji, Ning Duan, Yan-Kui Wang, Jing-Yi Zhou, Li-Hui Wei, Xiang-Jun He, Jian-Liu Wang, Xiao-Ping Li, Li-Shao Guo |
| Source: | Chinese Medical Journal, Vol 132, Iss 13, Pp 1550-1562 (2019) |
| Publisher Information: | Wolters Kluwer, 2019. |
| Publication Year: | 2019 |
| Collection: | LCC:Medicine |
| Subject Terms: | Medicine |
| More Details: | Abstract. Background:. Management of tumors has become more complex owing to tumor heterogeneity. Fewer studies have been performed on intra-tumor heterogeneity of endometrial cancer (EC) until now. Therefore, it is of great clinical value to explore the intra-tumor heterogeneity of EC based on clinical features and gene expression profiles. Methods:. A total of 1688 patients with EC were screened and 114 patients were finally selected, including specimens from 84 patients with primary EC without relapse (PE) and the paired metastases (P-M) specimens, as well as specimens from 30 patients with primary EC with relapse (RPE) and the paired relapsed EC (P-RE) specimens. Microarray and RNA-seq were used to detect gene expression of EC samples. Clinicopathological characteristics and molecular data were compared between PE and P-M groups and between RPE and P-RE groups to explore the intra-tumor heterogeneity of EC. Results:. The clinical intra-tumor spatial heterogeneity of pathological type, grade, ER status, and PR status between PE and P-M were 17.9%, 13.1%, 28.6%, and 28.6%, respectively. The clinical intra-tumor spatiotemporal heterogeneity of pathological type, grade, ER status, and PR status between RPE and P-RE were 16.7%, 33.3%, 25.0%, and 37.5%, respectively. Cluster analysis sorts EC samples based on progression type of lesion and their pathological type. There were differentially expressed genes between PE and P-M and between RPE and P-RE, of which gene ontology and Kyoto Encyclopedia of Genes and Genomes analysis were mainly enriched in cell proliferation, the p53 signaling pathway, etc. Conclusions:. Clinical and molecular data showed that there was spatiotemporal heterogeneity in intra-tumor of EC, which may add to the complexity of diagnosis and therapeutics for EC. Considering the intra-tumor heterogeneity, sequential chemotherapy and precision medicine may be a more suitable treatment plan for EC. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0366-6999 2542-5641 00000000 |
| Relation: | http://journals.lww.com/10.1097/CM9.0000000000000286; https://doaj.org/toc/0366-6999; https://doaj.org/toc/2542-5641 |
| DOI: | 10.1097/CM9.0000000000000286 |
| Access URL: | https://doaj.org/article/cb4cea65b66d4634a07322a0bd3ccace |
| Accession Number: | edsdoj.b4cea65b66d4634a07322a0bd3ccace |
| Database: | Directory of Open Access Journals |
| ISSN: | 03666999 25425641 00000000 |
|---|---|
| DOI: | 10.1097/CM9.0000000000000286 |
| Published in: | Chinese Medical Journal |
| Language: | English |