Sero-catalytic and Antibody Acquisition Models to Estimate Differing Malaria Transmission Intensities in Western Kenya

Bibliographic Details
Title: Sero-catalytic and Antibody Acquisition Models to Estimate Differing Malaria Transmission Intensities in Western Kenya
Authors: Grace E. Weber, Michael T. White, Anna Babakhanyan, Peter Odada Sumba, John Vulule, Dylan Ely, Chandy John, Evelina Angov, David Lanar, Sheetij Dutta, David L. Narum, Toshihiro Horii, Alan Cowman, James Beeson, Joseph Smith, James W. Kazura, Arlene E. Dent
Source: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Publisher Information: Nature Portfolio, 2017.
Publication Year: 2017
Collection: LCC:Medicine
LCC:Science
Subject Terms: Medicine, Science
More Details: Abstract We sought to identify a subset of Plasmodium falciparum antibody targets that would inform monitoring efforts needed to eliminate malaria in high transmission settings. IgG antibodies to 28 recombinant Pf antigens were measured in residents of two communities in western Kenya examined in 2003 and 2013, when the respective prevalence of asymptomatic parasitemia among children was 81 and 15 percent by microscopy. Annual seroconversion rates based on a sero-catalytic model that dichotomised antibody values to negative versus positive showed that rates were higher in 2003 than 2013 for 1 pre-erythrocytic and 7 blood-stage antigens. Antibody acquisition models that considered antibody levels as continuous variables showed that age-related antibody levels to Circumsporozoite Protein and 10 merozoite proteins increased at different rates with age in 2003 versus 2013. Both models found that antibodies to 5 proteins of the Merozoite Surface Protein 1 complex were differentially acquired between the cohorts, and that changes in antibody levels to Apical Membrane Antigen 1 suggested a decrease in transmission that occurred ~10 years before 2013. Further studies evaluating antibodies to this subset of Pf antigens as biomarkers of malaria exposure and naturally acquired immunity are warranted in endemic settings where transmission has been reduced but persists.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-017-17084-9
Access URL: https://doaj.org/article/b4b23d2c9c8c47a69405060fca7a2b2d
Accession Number: edsdoj.b4b23d2c9c8c47a69405060fca7a2b2d
Database: Directory of Open Access Journals
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More Details
ISSN:20452322
DOI:10.1038/s41598-017-17084-9
Published in:Scientific Reports
Language:English