Academic Journal
Sex differences underlying pancreatic islet biology and its dysfunction
| Title: | Sex differences underlying pancreatic islet biology and its dysfunction |
|---|---|
| Authors: | Maureen Gannon, Rohit N. Kulkarni, Hubert M. Tse, Franck Mauvais-Jarvis |
| Source: | Molecular Metabolism, Vol 15, Iss , Pp 82-91 (2018) |
| Publisher Information: | Elsevier, 2018. |
| Publication Year: | 2018 |
| Collection: | LCC:Internal medicine |
| Subject Terms: | Internal medicine, RC31-1245 |
| More Details: | Background: The sex of an individual affects glucose homeostasis and the pathophysiology, incidence, and prevalence of diabetes as well as the response to therapy. Scope of the review: This review focuses on clinical and experimental sex differences in islet cell biology and dysfunction during development and in adulthood in human and animal models. We discuss sex differences in β-cell and α-cell function, heterogeneity, and dysfunction. We cover sex differences in communication between gonads and islets and islet-cell immune interactions. Finally, we discuss sex differences in β-cell programming by nutrition and other environmental factors during pregnancy. Major conclusions: Important sex differences exist in islet cell function and susceptibility to failure. These differences represent sex-related biological factors that can be harnessed for gender-based prevention of and therapy for diabetes. Keywords: Sex differences, Gender differences, Islet, β-cell, α-cell, Diabetes, Immune cells |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2212-8778 21894000 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2212877818305209; https://doaj.org/toc/2212-8778 |
| DOI: | 10.1016/j.molmet.2018.05.017 |
| Access URL: | https://doaj.org/article/b3e58fedd55541b2981de218940005ca |
| Accession Number: | edsdoj.b3e58fedd55541b2981de218940005ca |
| Database: | Directory of Open Access Journals |
| ISSN: | 22128778 21894000 |
|---|---|
| DOI: | 10.1016/j.molmet.2018.05.017 |
| Published in: | Molecular Metabolism |
| Language: | English |