Bibliographic Details
| Title: |
Integrins are required for synchronous ommatidial rotation in the Drosophila eye linking planar cell polarity signalling to the extracellular matrix |
| Authors: |
Maria Thuveson, Konstantin Gaengel, Giovanna M. Collu, Mei-ling Chin, Jaskirat Singh, Marek Mlodzik |
| Source: |
Open Biology, Vol 9, Iss 8 (2019) |
| Publisher Information: |
The Royal Society, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Biology (General) |
| Subject Terms: |
planar cell polarity, drosophila eye, ommatidial rotation, integrins, extracellular matrix, Biology (General), QH301-705.5 |
| More Details: |
Integrins mediate the anchorage between cells and their environment, the extracellular matrix (ECM), and form transmembrane links between the ECM and the cytoskeleton, a conserved feature throughout development and morphogenesis of epithelial organs. Here, we demonstrate that integrins and components of the ECM are required during the planar cell polarity (PCP) signalling-regulated cell movement of ommatidial rotation in the Drosophila eye. The loss-of-function mutations of integrins or ECM components cause defects in rotation, with mutant clusters rotating asynchronously compared to wild-type clusters. Initially, mutant clusters tend to rotate faster, and at later stages they fail to be synchronous with their neighbours, leading to aberrant rotation angles and resulting in a disorganized ommatidial arrangement in adult eyes. We further demonstrate that integrin localization changes dynamically during the rotation process. Our data suggest that core Frizzled/PCP factors, acting through RhoA and Rho kinase, regulate the function/activity of integrins and that integrins thus contribute to the complex interaction network of PCP signalling, cell adhesion and cytoskeletal elements required for a precise and synchronous 90° rotation movement. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2046-2441 |
| Relation: |
https://doaj.org/toc/2046-2441 |
| DOI: |
10.1098/rsob.190148 |
| Access URL: |
https://doaj.org/article/b3dc80d58cb74c9aadfa9c79e3315739 |
| Accession Number: |
edsdoj.b3dc80d58cb74c9aadfa9c79e3315739 |
| Database: |
Directory of Open Access Journals |
