Proliferating cell nuclear antigen (PCNA) expression in pituitary adenomas: relationship to the endocrine phenotype of adenoma.
| Title: | Proliferating cell nuclear antigen (PCNA) expression in pituitary adenomas: relationship to the endocrine phenotype of adenoma. |
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| Authors: | Andrzej Radek, Jolanta Kunert-Radek, Katarzyna Winczyk, Ilona Kurnatowska, Anna Gruszka, Marek Pawlikowski |
| Source: | Folia Histochemica et Cytobiologica, Vol 44, Iss 1, Pp 37-41 (2006) |
| Publisher Information: | Via Medica, 2006. |
| Publication Year: | 2006 |
| Collection: | LCC:Cytology |
| Subject Terms: | Cytology, QH573-671 |
| More Details: | The expression of proliferating cell nuclear antigen (PCNA) correlates to cell proliferation and for this reason it is commonly considered as one of proliferation markers. Since proliferation rate is an important factor determining the tumor aggressiveness, the evaluation of PCNA index (the percentage of PCNA-immunopositive nuclei in the investigated tumor sample) is suggested as useful in predicting pituitary adenoma outcome. Seventy three unselected, surgically removed pituitary adenomas were immunostained with antibodies against the pituitary hormones or their subunits and against the proliferating cell nuclear antigen (PCNA). The highest PCNA index was found in ACTH-immunopositive tumors without the manifestation of the Cushing's disease ("silent" corticotropinomas). This value was significantly different in comparison to other adenoma subtypes including corticotropinomas manifesting themselves by Cushing's disease. The lowest PCNA index was noticed in monohormonal GH-secreting tumors. The adenomas which express more than one hormone (plurihormonal adenomas) seem to have a higher PCNA indices than monohormonal ones; the difference was significant in the case of mono- and plurihormonal prolactinomas. The recurrent tumors presented a higher mean PCNA index as compared to the primary tumors, although the difference was significant only in the case of prolactinomas. These findings suggest that the proliferative potential of pituitary adenomas is related to the tumor recurrence and hormone expression. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0239-8508 1897-5631 |
| Relation: | http://czasopisma.viamedica.pl/fhc/article/view/4586; https://doaj.org/toc/0239-8508; https://doaj.org/toc/1897-5631 |
| DOI: | 10.5603/4586 |
| Access URL: | https://doaj.org/article/db3c923594de41678f1e4e90fc17e1ca |
| Accession Number: | edsdoj.b3c923594de41678f1e4e90fc17e1ca |
| Database: | Directory of Open Access Journals |
| ISSN: | 02398508 18975631 |
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| DOI: | 10.5603/4586 |
| Published in: | Folia Histochemica et Cytobiologica |
| Language: | English |