Oxidative Stress: A Comprehensive Review of Biochemical, Molecular, and Genetic Aspects in the Pathogenesis and Management of Varicocele
| Title: | Oxidative Stress: A Comprehensive Review of Biochemical, Molecular, and Genetic Aspects in the Pathogenesis and Management of Varicocele |
|---|---|
| Authors: | Renata Finelli, Kristian Leisegang, Hussein Kandil, Ashok Agarwal |
| Source: | The World Journal of Men's Health, Vol 40, Iss 1, Pp 87-103 (2022) |
| Publisher Information: | Korean Society for Sexual Medicine and Andrology, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Medicine LCC:Diseases of the genitourinary system. Urology |
| Subject Terms: | dna damage, genomics, male infertility, oxidative stress, proteomics, reactive oxygen species, Medicine, Diseases of the genitourinary system. Urology, RC870-923 |
| More Details: | Oxidative stress is a condition due to an imbalance between the concentrations of oxidants and antioxidants, and it is a wellrecognized contributor in several male infertility conditions. Varicocele, a common vascular condition, may cause male infertility due to hyperthermia, hypoxia and/or exposure to toxic adrenal and renal metabolites. In this review, the mechanisms by which oxidative stress can affect cellular integrity and functions are described, along with molecular markers of cellular oxidative damage, and the most commonly performed techniques for their detection in seminal fluid. Moreover, we focus on the role of oxidative stress in the pathophysiology of varicocele based on recently published evidence from omics based studies, such as proteomics and genomics. Finally, we discuss strategies for the management of oxidative stress and the clinical guidelines for testing oxidative stress-related sperm DNA fragmentation in this group of patients. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2287-4208 2287-4690 |
| Relation: | https://doaj.org/toc/2287-4208; https://doaj.org/toc/2287-4690 |
| DOI: | 10.5534/wjmh.210153 |
| Access URL: | https://doaj.org/article/b3bc2a2f5b4f4406ac45eced042b3b73 |
| Accession Number: | edsdoj.b3bc2a2f5b4f4406ac45eced042b3b73 |
| Database: | Directory of Open Access Journals |
| ISSN: | 22874208 22874690 |
|---|---|
| DOI: | 10.5534/wjmh.210153 |
| Published in: | The World Journal of Men's Health |
| Language: | English |