Academic Journal
Dietary flavonoid intake is negatively associated with accelerating aging: an American population-based cross-sectional study
| Title: | Dietary flavonoid intake is negatively associated with accelerating aging: an American population-based cross-sectional study |
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| Authors: | Jintao Zhong, Jiamin Fang, Yixuan Wang, Pinli Lin, Biyu Wan, Mengya Wang, Lili Deng, Xiaona Tang |
| Source: | Nutrition Journal, Vol 23, Iss 1, Pp 1-14 (2024) |
| Publisher Information: | BMC, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Nutrition. Foods and food supply LCC:Nutritional diseases. Deficiency diseases |
| Subject Terms: | Flavonoid, Aging, Flavones, NHANES, Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627 |
| More Details: | Abstract Background Flavonoids are believed to have potential anti-aging effects due to their anti-inflammatory and antioxidant properties. However, the effectiveness of dietary flavonoids and their subclasses in delaying aging has yet to be confirmed. Our study intends to examine relationship between them. Methods Data from three survey cycles (2007–2008, 2009–2010, and 2017–2018) of the National Health and Nutrition Examination Survey (NHANES) was used to investigate the relationship between PhenoAgeAccel and dietary flavonoid intake. Weighted linear regression was conducted to evaluate the relationship between dietary flavonoid intake and PhenoAgeAccel, and the dose-response relationship was investigated by limited cubic spline (RCS) analysis. Mixed effects were explored using weighted quantile sum (WQS) regression. Further, the subgroup analyses were also conducted. Results A total of 5391 participants were included, after multivariable adjustments, a negative association was found with total dietary flavonoid, flavan-3-ols, flavanone, flavones and flavonols with a β (95% CI) of -0.87 ( -1.61, -0.13), -0.83 (-1.95, -0.08), -1.18 (-1.98, -0.39), -1.64 (-2.52, -0.77) and − 1.18 (-1.98, -0.39) for the higher quintile compared to the lowest quintile. The RCS analysis show a non-linear relationship between flavan-3-ols (P for nonlinear = 0.024), flavanones (P for nonlinear = 0.005), flavones (P for nonlinear |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1475-2891 |
| Relation: | https://doaj.org/toc/1475-2891 |
| DOI: | 10.1186/s12937-024-01052-x |
| Access URL: | https://doaj.org/article/cb37ef21709b4fbb97cf7b9f80e214db |
| Accession Number: | edsdoj.b37ef21709b4fbb97cf7b9f80e214db |
| Database: | Directory of Open Access Journals |
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| ISSN: | 14752891 |
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| DOI: | 10.1186/s12937-024-01052-x |
| Published in: | Nutrition Journal |
| Language: | English |