Academic Journal
Prevalence of Adverse Events and Hypoglycemia in Patients with Type 2 Diabetes Treated with Novel Antidiabetic Medications
| Title: | Prevalence of Adverse Events and Hypoglycemia in Patients with Type 2 Diabetes Treated with Novel Antidiabetic Medications |
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| Authors: | Ebrahim Mohammadi, Laya Hooshmand, Arash Masumi |
| Source: | Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, Vol 28, Iss 1, Pp 43-52 (2025) |
| Publisher Information: | Arak Medical University, 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Medicine LCC:Medicine (General) |
| Subject Terms: | drug‑induced hypoglycemia, adverse event, relative frequency, type‑2 diabetes mellitus, Medicine, Medicine (General), R5-920 |
| More Details: | Introduction: Novel antidiabetic medications are employed to manage glycemic control and mitigate the long-term complications of type 2 diabetes. This study aimed to investigate the prevalence of adverse events, including hypoglycemia, associated with these novel antidiabetic agents in a cohort of patients with type 2 diabetes. Methods: This cross-sectional analytical study was conducted on 157 patients with type 2 diabetes mellitus attending the Endocrinology Clinic at Imam Khomeini Hospital, Urmia, during the summer of 2024. A convenience sampling method was employed to recruit participants. Data on demographics, the incidence of hypoglycemia, and reported adverse drug reactions were collected from all eligible patients through a structured interview. Subsequently, patients were stratified into three treatment groups based on the specific novel antidiabetic medication they received. Results: In patients receiving sitagliptin, the most prevalent adverse events included arthralgia and rheumatic problems (26.31%), dermatological manifestations (36.84%), and allergic reactions (21.06%). Nausea (52.94%) and abdominal pain (17.65%) were the most frequent adverse events observed in patients treated with liraglutide. Polydipsia (28.72%), weakness and lethargy (26.6%), and dry mucous membranes (27.66%) were commonly reported in patients receiving empagliflozin. Hypoglycemia was observed predominantly in male patients aged 51-55 years receiving sitagliptin. Conclusions: The findings of this study demonstrate a low incidence of hypoglycemia among patients treated with modern antidiabetic medications. Prevalent short-term adverse events observed included gastrointestinal disturbances, allergic reactions, and dermatological manifestations. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | Persian |
| ISSN: | 1735-5338 2008-644X |
| Relation: | http://jams.arakmu.ac.ir/article-1-7908-en.pdf; https://doaj.org/toc/1735-5338; https://doaj.org/toc/2008-644X |
| Access URL: | https://doaj.org/article/b3630b8942474e1f9ccb99efddbd80ef |
| Accession Number: | edsdoj.b3630b8942474e1f9ccb99efddbd80ef |
| Database: | Directory of Open Access Journals |
| ISSN: | 17355338 2008644X |
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| Published in: | Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk |
| Language: | Persian |