Bibliographic Details
| Title: |
Comparing Trabeculectomy Outcomes between First and Second Operated Eyes: A Multicenter Study. |
| Authors: |
Kentaro Iwasaki, Yoshihiro Takamura, Takashi Nishida, Akira Sawada, Keiichiro Iwao, Ayano Shinmura, Shiho Kunimatsu-Sanuki, Tetsuya Yamamoto, Hidenobu Tanihara, Kazuhisa Sugiyama, Toru Nakazawa, Masaru Inatani |
| Source: |
PLoS ONE, Vol 11, Iss 9, p e0162569 (2016) |
| Publisher Information: |
Public Library of Science (PLoS), 2016. |
| Publication Year: |
2016 |
| Collection: |
LCC:Medicine
LCC:Science |
| Subject Terms: |
Medicine, Science |
| More Details: |
OBJECTIVE:To compare surgical outcomes between the first and second operated eyes in patients who underwent trabeculectomy in both eyes. METHODS:This retrospective clinical cohort study at five clinical centers in Japan included 84 patients with open-angle glaucoma who underwent primary trabeculectomy in both eyes. The primary outcome was surgical success or failure, with failure being defined according to three criteria: 21 mmHg; Criterion B, IOP >18 mmHg; or Criterion C, IOP >15 mmHg. Cases of reoperation, a loss of light perception vision, or hypotony were also considered as "failures". RESULTS:There were no significant differences in success rate for any of the three criteria between the first and second operated eyes. For patients whose first trabeculectomy was successful, when the second trabeculectomy was performed ≥2 months after the first, the survival curves for all three criteria for the second trabeculectomy were significantly worse than those for patients waiting a shorter interval between trabeculectomies (Criterion A, 52.0% vs 83.6%, P = 0.0031; Criterion B, 51.5% vs 80.4%, P = 0.026; Criterion C, 51.1% vs 80.4%, P = 0.048). In multivariable analyses, a longer interval between trabeculectomies was a significant prognostic factor for surgical failure (Criterion A, P = 0.0055; Criterion B, P = 0.0023; Criterion C, P = 0.027). However, no dependency on the interval between trabeculectomies was found among patients whose first trabeculectomy failed. CONCLUSIONS:If the first trabeculectomy is successful, a long interval before the second trabeculectomy increases the risk of surgical failure in the second eye. This result has clinical implications for developing surgical strategies for patients with bilateral glaucoma. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1932-6203 |
| Relation: |
http://europepmc.org/articles/PMC5021342?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: |
10.1371/journal.pone.0162569 |
| Access URL: |
https://doaj.org/article/db3344180794442fbdfdb035dc3ccf6f |
| Accession Number: |
edsdoj.b3344180794442fbdfdb035dc3ccf6f |
| Database: |
Directory of Open Access Journals |
