Academic Journal
Raised Alpha-Fetoprotein Level and its Association with Hepatocellular Carcinoma
| Title: | Raised Alpha-Fetoprotein Level and its Association with Hepatocellular Carcinoma |
|---|---|
| Authors: | Madiha Hashmi, Ghulam Haider, Muhammad Danish, Anusha Hassan, Razia Irshad, Khalil Ahmed |
| Source: | Pakistan Armed Forces Medical Journal, Vol 73, Iss 5 (2023) |
| Publisher Information: | Army Medical College Rawalpindi, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Medicine LCC:Medicine (General) |
| Subject Terms: | Alpha-fetoprotein, Child-Pugh score, Hepatocellular carcinoma, Hepatitis C, Hepatitis B, Liver cirrhosis, Medicine, Medicine (General), R5-920 |
| More Details: | Objective: To evaluate raised alpha feto-protein levels for socio-demographic and clinicopathological features in hepatocellular carcinoma. Study Design: Cross-sectional study. Place and Duration of Study: Department of Medical Oncology, Jinnah Postgraduate Medical Center, Karachi Pakistan, from Jan 2019 to Jan 2020. Methodology: Two hundred and thirty-six patients of age more than 20 years, of either gender diagnosed with hepatocellular carcinoma were included. Detailed demographic data, information regarding addiction and medical history were collected. According to The National Comprehensive Cancer Network, Hepatocellular carcinoma was diagnosed using a multiphasic liver protocol CT scan with intravenous contrast. The alpha-fetoprotein levels were checked after confirmation of hepatocellular carcinoma on a multiphasic CT scan. The cut-off value for elevated alpha feto-protein was ≥20 ng/mL. Results: The median alpha protein levels were reported as 411 ng/mL. About 183(78%) patients had elevated alpha protein levels. In univariate analysis, age, gender, diabetes mellitus, hepatitis B, hepatitis C, portal vein thrombosis, number of lesions, cirrhotic liver, features of portal hypertension, anti-viral treatment status, cigarette smoking, and segment of the liver showed a statistically significant relationship with elevated alpha protein levels (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0030-9648 2411-8842 |
| Relation: | https://www.pafmj.org/PAFMJ/article/view/5419; https://doaj.org/toc/0030-9648; https://doaj.org/toc/2411-8842 |
| DOI: | 10.51253/pafmj.v73i5.5419 |
| Access URL: | https://doaj.org/article/b32f5f316717452eb3b3f09d5d96a858 |
| Accession Number: | edsdoj.b32f5f316717452eb3b3f09d5d96a858 |
| Database: | Directory of Open Access Journals |
| Full text is not displayed to guests. | Login for full access. |
| ISSN: | 00309648 24118842 |
|---|---|
| DOI: | 10.51253/pafmj.v73i5.5419 |
| Published in: | Pakistan Armed Forces Medical Journal |
| Language: | English |