Genomic epidemiology of COVID-19 in care homes in the east of England
| Title: | Genomic epidemiology of COVID-19 in care homes in the east of England |
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| Authors: | William L Hamilton, Gerry Tonkin-Hill, Emily R Smith, Dinesh Aggarwal, Charlotte J Houldcroft, Ben Warne, Luke W Meredith, Myra Hosmillo, Aminu S Jahun, Martin D Curran, Surendra Parmar, Laura G Caller, Sarah L Caddy, Fahad A Khokhar, Anna Yakovleva, Grant Hall, Theresa Feltwell, Malte L Pinckert, Iliana Georgana, Yasmin Chaudhry, Colin S Brown, Sonia Gonçalves, Roberto Amato, Ewan M Harrison, Nicholas M Brown, Mathew A Beale, Michael Spencer Chapman, David K Jackson, Ian Johnston, Alex Alderton, John Sillitoe, Cordelia Langford, Gordon Dougan, Sharon J Peacock, Dominic P Kwiatowski, Ian G Goodfellow, M Estee Torok, COVID-19 Genomics Consortium UK |
| Source: | eLife, Vol 10 (2021) |
| Publisher Information: | eLife Sciences Publications Ltd, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Medicine LCC:Science LCC:Biology (General) |
| Subject Terms: | COVID-19, SARS-CoV-2, genomics, epidemiology, Medicine, Science, Biology (General), QH301-705.5 |
| More Details: | COVID-19 poses a major challenge to care homes, as SARS-CoV-2 is readily transmitted and causes disproportionately severe disease in older people. Here, 1167 residents from 337 care homes were identified from a dataset of 6600 COVID-19 cases from the East of England. Older age and being a care home resident were associated with increased mortality. SARS-CoV-2 genomes were available for 700 residents from 292 care homes. By integrating genomic and temporal data, 409 viral clusters within the 292 homes were identified, indicating two different patterns – outbreaks among care home residents and independent introductions with limited onward transmission. Approximately 70% of residents in the genomic analysis were admitted to hospital during the study, providing extensive opportunities for transmission between care homes and hospitals. Limiting viral transmission within care homes should be a key target for infection control to reduce COVID-19 mortality in this population. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2050-084X |
| Relation: | https://elifesciences.org/articles/64618; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.64618 |
| Access URL: | https://doaj.org/article/b27c3a56813c416cbfa05ed0311ba726 |
| Accession Number: | edsdoj.b27c3a56813c416cbfa05ed0311ba726 |
| Database: | Directory of Open Access Journals |
| ISSN: | 2050084X |
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| DOI: | 10.7554/eLife.64618 |
| Published in: | eLife |
| Language: | English |