Bibliographic Details
| Title: |
Survival, but not the severity of hypoxic–ischemic encephalopathy, is associated with higher mean arterial blood pressure after cardiac arrest: a retrospective cohort study |
| Authors: |
Sandra Preuß, Jan Multmeier, Werner Stenzel, Sebastian Major, Christoph J. Ploner, Christian Storm, Jens Nee, Christoph Leithner, Christian Endisch |
| Source: |
Frontiers in Cardiovascular Medicine, Vol 11 (2024) |
| Publisher Information: |
Frontiers Media S.A., 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: |
cardiac arrest (CA), brain autopsy, hypoxic–ischemic encephalopathy (HIE), mean arterial pressure (MAP), cumulative vasopressor index, prognosis, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: |
BackgroundThis study investigates the association between the mean arterial blood pressure (MAP), vasopressor requirement, and severity of hypoxic–ischemic encephalopathy (HIE) after cardiac arrest (CA).MethodsBetween 2008 and 2017, we retrospectively analyzed the MAP 200 h after CA and quantified the vasopressor requirements using the cumulative vasopressor index (CVI). Through a postmortem brain autopsy in non-survivors, the severity of the HIE was histopathologically dichotomized into no/mild and severe HIE. In survivors, we dichotomized the severity of HIE into no/mild cerebral performance category (CPC) 1 and severe HIE (CPC 4). We investigated the regain of consciousness, causes of death, and 5-day survival as hemodynamic confounders.ResultsAmong the 350 non-survivors, 117 had histopathologically severe HIE while 233 had no/mild HIE, without differences observed in the MAP (73.1 vs. 72.0 mmHg, pgroup = 0.639). Compared to the non-survivors, 211 patients with CPC 1 and 57 patients with CPC 4 had higher MAP values that showed significant, but clinically non-relevant, MAP differences (81.2 vs. 82.3 mmHg, pgroup |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2297-055X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fcvm.2024.1337344/full; https://doaj.org/toc/2297-055X |
| DOI: |
10.3389/fcvm.2024.1337344 |
| Access URL: |
https://doaj.org/article/b1e770928bde474e96247bf47f01b49c |
| Accession Number: |
edsdoj.b1e770928bde474e96247bf47f01b49c |
| Database: |
Directory of Open Access Journals |
