| Title: |
miR-193-5p negatively regulates PIK3CD to promote crop fibrocyte proliferation in pigeon (Columba livia) |
| Authors: |
Hui Ma, Pingzhuang Ge, Shixiong Bian, Yunlei Li, Aixin Ni, Ran Zhang, Yuanmei Wang, Jinmeng Zhao, Yunhe Zong, Jingwei Yuan, Yanyan Sun, Jilan Chen |
| Source: |
Poultry Science, Vol 102, Iss 2, Pp 102378- (2023) |
| Publisher Information: |
Elsevier, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Animal culture |
| Subject Terms: |
PIK3CD, miR-193-5p, crop fibrocyte, cell proliferation, pigeon, Animal culture, SF1-1100 |
| More Details: |
ABSTRACT: The crop of pigeon has specific characteristics as producing crop milk in the lactating period. However, the exact mechanisms underlying the regulation of crop lactation remain unclear. miRNAs, the essential regulators of gene expression, are implicated in various physiological and biological activities. In this study, we discovered a new miRNA that regulated phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta (PIK3CD) and crop fibrocyte proliferation. Results of the luciferase reporter assay suggested that miR-193-5p suppressed PIK3CD expression by targeting a conserved binding site in the 3′-untranslated region (UTR) of PIK3CD mRNA. MiR-193-5p promoted crop fibrocyte proliferation and migration, whereas PIK3CD inhibited these effects. These findings suggested an important regulatory role of miR-193-5p in crop fibrocyte proliferation, suggesting that miR-193-5p and PIK3CD might be important regulators of crop milk production. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
0032-5791 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S0032579122006721; https://doaj.org/toc/0032-5791 |
| DOI: |
10.1016/j.psj.2022.102378 |
| Access URL: |
https://doaj.org/article/b1cb891261bf4323a4dbd381cc768e0b |
| Accession Number: |
edsdoj.b1cb891261bf4323a4dbd381cc768e0b |
| Database: |
Directory of Open Access Journals |
