Bibliographic Details
| Title: |
Associations between self-reported diabetes and 78 circulating markers of inflammation, immunity, and metabolism among adults in the United States. |
| Authors: |
Alison L Van Dyke, Krystle A Lang Kuhs, Meredith S Shiels, Jill Koshiol, Britton Trabert, Erikka Loftfield, Mark P Purdue, Nicolas Wentzensen, Ruth M Pfeiffer, Hormuzd A Katki, Allan Hildesheim, Troy J Kemp, Ligia A Pinto, Anil K Chaturvedi, Mahboobeh Safaeian |
| Source: |
PLoS ONE, Vol 12, Iss 7, p e0182359 (2017) |
| Publisher Information: |
Public Library of Science (PLoS), 2017. |
| Publication Year: |
2017 |
| Collection: |
LCC:Medicine
LCC:Science |
| Subject Terms: |
Medicine, Science |
| More Details: |
Inflammation is increasingly thought to be associated with diabetes; however, only a few inflammation markers have been assessed concurrently in relation to history of diabetes. In the most comprehensive evaluation of inflammation markers and diabetes to date using a Luminex bead-based assay, we measured 78 inflammation-, immune-, and metabolic-related markers detectable in at least 10% of serum samples collected from participants from the Prostate, Lung, Colorectal and Ovarian Cancer (PLCO) screening trial (n = 1,814). At baseline, 6.6% (n = 120) of PLCO participants self-reported a history of diabetes. Cross-sectional associations between these markers and self-reported diabetes were assessed using weighted logistic regression adjusting for sex, smoking status, blood draw age and year, body mass index, and cohort sub-study. Including chemokines [C-C motif ligand (CCL) 19, CCL20, CCL21, C-X-C motif ligand (CXCL) 6, CXCL10, and CXCL11] and soluble cytokine and chemokine receptors [soluble (s) interleukin (IL) 6 receptor (R), soluble tumor necrosis factor receptor (sTNFR) 1, sTNFR2, and sIL-R2], ten inflammation-related markers, were nominally associated with diabetes (P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1932-6203 |
| Relation: |
http://europepmc.org/articles/PMC5533447?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: |
10.1371/journal.pone.0182359 |
| Access URL: |
https://doaj.org/article/db1a0ce393714d5a9f31a4f23a719049 |
| Accession Number: |
edsdoj.b1a0ce393714d5a9f31a4f23a719049 |
| Database: |
Directory of Open Access Journals |
