Bibliographic Details
| Title: |
Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19 |
| Authors: |
Salvador Espino-y-Sosa, Raigam Jafet Martinez-Portilla, Johnatan Torres-Torres, Juan Mario Solis-Paredes, Guadalupe Estrada-Gutierrez, Jose Antonio Hernandez-Pacheco, Aurora Espejel-Nuñez, Paloma Mateu-Rogell, Angeles Juarez-Reyes, Francisco Eduardo Lopez-Ceh, Jose Rafael Villafan-Bernal, Lourdes Rojas-Zepeda, Iris Paola Guzman-Guzman, Liona C. Poon |
| Source: |
Viruses, Vol 13, Iss 10, p 1906 (2021) |
| Publisher Information: |
MDPI AG, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Microbiology |
| Subject Terms: |
COVID-19, maternal death, angiotensin-II, sFlt-1, Microbiology, QR1-502 |
| More Details: |
Background: In healthy pregnancies, components of the Renin-Angiotensin system (RAS) are present in the placental villi and contribute to invasion, migration, and angiogenesis. At the same time, soluble fms-like tyrosine kinase 1 (sFlt-1) production is induced after binding of ANG-II to its receptor (AT-1R) in response to hypoxia. As RAS plays an essential role in the pathogenesis of COVID-19, we hypothesized that angiogenic marker (sFlt-1) and RAS components (ANG-II and ACE-2) may be related to adverse outcomes in pregnant women with COVID-19; Methods: Prospective cohort study. Primary outcome was severe pneumonia. Secondary outcomes were ICU admission, intubation, sepsis, and death. Spearman’s Rho test was used to analyze the correlation between sFlt-1 and ANG-II levels. The sFlt-1/ANG-II ratio was determined and the association with each adverse outcome was explored by logistic regression analysis and the prediction was assessed using receiver-operating-curve (ROC); Results: Among 80 pregnant women with COVID-19, the sFlt-1/ANG-II ratio was associated with an increased probability of severe pneumonia (odds ratio [OR]: 1.31; p = 0.003), ICU admission (OR: 1.05; p = 0.007); intubation (OR: 1.09; p = 0.008); sepsis (OR: 1.04; p = 0.008); and death (OR: 1.04; p = 0.018); Conclusion: sFlt-1/ANG-II ratio is a good predictor of adverse events such as pneumonia, ICU admission, intubation, sepsis, and death in pregnant women with COVID-19. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1999-4915 |
| Relation: |
https://www.mdpi.com/1999-4915/13/10/1906; https://doaj.org/toc/1999-4915 |
| DOI: |
10.3390/v13101906 |
| Access URL: |
https://doaj.org/article/b19d5364048d479fb8dbeea3e430bf96 |
| Accession Number: |
edsdoj.b19d5364048d479fb8dbeea3e430bf96 |
| Database: |
Directory of Open Access Journals |
