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EBF1, MYO6 and CALR expression levels predict therapeutic response in diffuse large B-cell lymphomas

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Title: EBF1, MYO6 and CALR expression levels predict therapeutic response in diffuse large B-cell lymphomas
Authors: Alice Turdo, Miriam Gaggianesi, Caterina D’Accardo, Gaetana Porcelli, Sebastiano Di Bella, Dario Cricchio, Irene Pillitteri, Rossana Porcasi, Melania Lo Iacono, Francesco Verona, Chiara Modica, Narges Roozafzay, Ada Maria Florena, Giorgio Stassi, Salvatrice Mancuso, Matilde Todaro
Source: Frontiers in Immunology, Vol 14 (2023)
Publisher Information: Frontiers Media S.A., 2023.
Publication Year: 2023
Collection: LCC:Immunologic diseases. Allergy
Subject Terms: diffuse large B-cell lymphoma, R-CHOP, therapy resistance, elderly patients, gene expression signature, biomarkers of response, Immunologic diseases. Allergy, RC581-607
More Details: BackgroundDiffuse large B-cell lymphoma (DLBCL) is a hematological malignancy representing one-third of non-Hodgkin’s lymphoma cases. Notwithstanding immunotherapy in combination with chemotherapy (R-CHOP) is an effective therapeutic approach for DLBCL, a subset of patients encounters treatment resistance, leading to low survival rates. Thus, there is an urgent need to identify predictive biomarkers for DLBCL including the elderly population, which represents the fastest-growing segment of the population in Western countries.MethodsGene expression profiles of n=414 DLBCL biopsies were retrieved from the public dataset GSE10846. Differentially expressed genes (DEGs) (fold change >1.4, p-value
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1664-3224
Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1266265/full; https://doaj.org/toc/1664-3224
DOI: 10.3389/fimmu.2023.1266265
Access URL: https://doaj.org/article/b198c3f32aad41e698a82358a2a2963c
Accession Number: edsdoj.b198c3f32aad41e698a82358a2a2963c
Database: Directory of Open Access Journals
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  Data: EBF1, MYO6 and CALR expression levels predict therapeutic response in diffuse large B-cell lymphomas
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  Data: <searchLink fieldCode="AR" term="%22Alice+Turdo%22">Alice Turdo</searchLink><br /><searchLink fieldCode="AR" term="%22Miriam+Gaggianesi%22">Miriam Gaggianesi</searchLink><br /><searchLink fieldCode="AR" term="%22Caterina+D%27Accardo%22">Caterina D’Accardo</searchLink><br /><searchLink fieldCode="AR" term="%22Gaetana+Porcelli%22">Gaetana Porcelli</searchLink><br /><searchLink fieldCode="AR" term="%22Sebastiano+Di+Bella%22">Sebastiano Di Bella</searchLink><br /><searchLink fieldCode="AR" term="%22Dario+Cricchio%22">Dario Cricchio</searchLink><br /><searchLink fieldCode="AR" term="%22Irene+Pillitteri%22">Irene Pillitteri</searchLink><br /><searchLink fieldCode="AR" term="%22Rossana+Porcasi%22">Rossana Porcasi</searchLink><br /><searchLink fieldCode="AR" term="%22Melania+Lo+Iacono%22">Melania Lo Iacono</searchLink><br /><searchLink fieldCode="AR" term="%22Francesco+Verona%22">Francesco Verona</searchLink><br /><searchLink fieldCode="AR" term="%22Chiara+Modica%22">Chiara Modica</searchLink><br /><searchLink fieldCode="AR" term="%22Narges+Roozafzay%22">Narges Roozafzay</searchLink><br /><searchLink fieldCode="AR" term="%22Ada+Maria+Florena%22">Ada Maria Florena</searchLink><br /><searchLink fieldCode="AR" term="%22Giorgio+Stassi%22">Giorgio Stassi</searchLink><br /><searchLink fieldCode="AR" term="%22Salvatrice+Mancuso%22">Salvatrice Mancuso</searchLink><br /><searchLink fieldCode="AR" term="%22Matilde+Todaro%22">Matilde Todaro</searchLink>
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  Data: Frontiers in Immunology, Vol 14 (2023)
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  Data: Frontiers Media S.A., 2023.
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  Data: 2023
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  Data: LCC:Immunologic diseases. Allergy
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  Data: <searchLink fieldCode="DE" term="%22diffuse+large+B-cell+lymphoma%22">diffuse large B-cell lymphoma</searchLink><br /><searchLink fieldCode="DE" term="%22R-CHOP%22">R-CHOP</searchLink><br /><searchLink fieldCode="DE" term="%22therapy+resistance%22">therapy resistance</searchLink><br /><searchLink fieldCode="DE" term="%22elderly+patients%22">elderly patients</searchLink><br /><searchLink fieldCode="DE" term="%22gene+expression+signature%22">gene expression signature</searchLink><br /><searchLink fieldCode="DE" term="%22biomarkers+of+response%22">biomarkers of response</searchLink><br /><searchLink fieldCode="DE" term="%22Immunologic+diseases%2E+Allergy%22">Immunologic diseases. Allergy</searchLink><br /><searchLink fieldCode="DE" term="%22RC581-607%22">RC581-607</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: BackgroundDiffuse large B-cell lymphoma (DLBCL) is a hematological malignancy representing one-third of non-Hodgkin’s lymphoma cases. Notwithstanding immunotherapy in combination with chemotherapy (R-CHOP) is an effective therapeutic approach for DLBCL, a subset of patients encounters treatment resistance, leading to low survival rates. Thus, there is an urgent need to identify predictive biomarkers for DLBCL including the elderly population, which represents the fastest-growing segment of the population in Western countries.MethodsGene expression profiles of n=414 DLBCL biopsies were retrieved from the public dataset GSE10846. Differentially expressed genes (DEGs) (fold change >1.4, p-value
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  Data: 1664-3224
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  Data: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1266265/full; https://doaj.org/toc/1664-3224
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        Value: 10.3389/fimmu.2023.1266265
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      – Text: English
    Subjects:
      – SubjectFull: diffuse large B-cell lymphoma
        Type: general
      – SubjectFull: R-CHOP
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      – SubjectFull: therapy resistance
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      – SubjectFull: gene expression signature
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      – SubjectFull: biomarkers of response
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      – SubjectFull: Immunologic diseases. Allergy
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      – SubjectFull: RC581-607
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      – TitleFull: EBF1, MYO6 and CALR expression levels predict therapeutic response in diffuse large B-cell lymphomas
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