Bibliographic Details
| Title: |
EBF1, MYO6 and CALR expression levels predict therapeutic response in diffuse large B-cell lymphomas |
| Authors: |
Alice Turdo, Miriam Gaggianesi, Caterina D’Accardo, Gaetana Porcelli, Sebastiano Di Bella, Dario Cricchio, Irene Pillitteri, Rossana Porcasi, Melania Lo Iacono, Francesco Verona, Chiara Modica, Narges Roozafzay, Ada Maria Florena, Giorgio Stassi, Salvatrice Mancuso, Matilde Todaro |
| Source: |
Frontiers in Immunology, Vol 14 (2023) |
| Publisher Information: |
Frontiers Media S.A., 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Immunologic diseases. Allergy |
| Subject Terms: |
diffuse large B-cell lymphoma, R-CHOP, therapy resistance, elderly patients, gene expression signature, biomarkers of response, Immunologic diseases. Allergy, RC581-607 |
| More Details: |
BackgroundDiffuse large B-cell lymphoma (DLBCL) is a hematological malignancy representing one-third of non-Hodgkin’s lymphoma cases. Notwithstanding immunotherapy in combination with chemotherapy (R-CHOP) is an effective therapeutic approach for DLBCL, a subset of patients encounters treatment resistance, leading to low survival rates. Thus, there is an urgent need to identify predictive biomarkers for DLBCL including the elderly population, which represents the fastest-growing segment of the population in Western countries.MethodsGene expression profiles of n=414 DLBCL biopsies were retrieved from the public dataset GSE10846. Differentially expressed genes (DEGs) (fold change >1.4, p-value |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2023.1266265/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2023.1266265 |
| Access URL: |
https://doaj.org/article/b198c3f32aad41e698a82358a2a2963c |
| Accession Number: |
edsdoj.b198c3f32aad41e698a82358a2a2963c |
| Database: |
Directory of Open Access Journals |
