Two-Hour Lactate Clearance Predicts Negative Outcome in Patients with Cardiorespiratory Insufficiency
| Title: | Two-Hour Lactate Clearance Predicts Negative Outcome in Patients with Cardiorespiratory Insufficiency |
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| Authors: | Sean Scott, Vittorio Antonaglia, Giovanna Guiotto, Fiorella Paladino, Fernando Schiraldi |
| Source: | Critical Care Research and Practice, Vol 2010 (2010) |
| Publisher Information: | Hindawi Limited, 2010. |
| Publication Year: | 2010 |
| Collection: | LCC:Medical emergencies. Critical care. Intensive care. First aid |
| Subject Terms: | Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9 |
| More Details: | Objective. To evaluate 2-hour lactate clearance as a prognostic marker in acute cardiorespiratory insufficiency. Design. Prospective observational study. Setting. Emergency Department (ED) and 16-bed medical High Dependency Unit (HDU). Methods and Main Results. 95 consecutive admissions from the ED for acute cardiorespiratory insufficiency were prospectively enrolled. Arterial lactate concentration was assessed at ED arrival and 1, 2, 6, and 24 hours later. The predictive value of 2-hour lactate clearance was evaluated for negative outcomes defined as hospital mortality or need for endotracheal intubation versus positive outcomes defined as discharge or transfer to a general medical ward. Logistic regression and ROC curves found 2-hour lactate clearance >15% was a strong predictor of negative outcome (P15% is highly predictive of positive outcome and may reassure clinicians that the therapeutic approach is appropriate. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2090-1305 2090-1313 |
| Relation: | https://doaj.org/toc/2090-1305; https://doaj.org/toc/2090-1313 |
| DOI: | 10.1155/2010/917053 |
| Access URL: | https://doaj.org/article/cb195a704c344000acf6e1d5ec61c58e |
| Accession Number: | edsdoj.b195a704c344000acf6e1d5ec61c58e |
| Database: | Directory of Open Access Journals |
| ISSN: | 20901305 20901313 |
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| DOI: | 10.1155/2010/917053 |
| Published in: | Critical Care Research and Practice |
| Language: | English |