Academic Journal
Association of Monoamine Oxidase A with Tumor Burden and Castration Resistance in Prostate Cancer
| Title: | Association of Monoamine Oxidase A with Tumor Burden and Castration Resistance in Prostate Cancer |
|---|---|
| Authors: | Meenakshi Meenu, MBBS, MD, DM, Vipin Kumar Verma, PhD, Amlesh Seth, MBBS, MS, MCh, Ranjit Kumar Sahoo, MBBS, MD, DM, Pooja Gupta, MBBS, MD, DM, Dharamvir Singh Arya, MBBS, MD, PhD |
| Source: | Current Therapeutic Research, Vol 93, Iss , Pp 100610- (2020) |
| Publisher Information: | Elsevier, 2020. |
| Publication Year: | 2020 |
| Collection: | LCC:Therapeutics. Pharmacology |
| Subject Terms: | Castration resistance, Monoamine oxidase A, Prostate cancer, Tumor burden, Therapeutics. Pharmacology, RM1-950 |
| More Details: | Background: Metastatic burden and aggressive behavior determine severity stratification and guide treatment decisions in prostate cancer (PCa). Monoamine oxidase A (MAOA) may promote tumor burden and drug/castration resistance in PCa. A positive association will pave the way for MAOA inhibitors such as moclobemide for PCa therapy. Objective: To analyze MAOA in peripheral blood mononuclear cells qualitatively and p38, c-Jun N-terminal kinases, nuclear factor kappa B, and their phosphorylated forms, vascular endothelial growth factor (angiogenesis), transforming growth factor beta, interleukin 6, and tumor necrosis factor-α (cytokines), Bcl-2 associated X, B-cell lymphoma 2, and P53 (apoptosis), prostate-specific membrane antigen, and epithelial cell adhesion molecules (surface markers) in plasma of patients with PCa. Methods: This was a 1-year pilot study in which patients with PCa were recruited and stratified into 2 groups and subgroups: treatment-naive with (M1) (n = 23) or without (M0) (n = 23) bone metastasis; hormone-sensitive prostate cancer (n = 26) or hormone/castration-resistant prostate cancer (n = 26). MAOA was detected using ELISA and other proteins were detected using immunoblotting technique. Results: MAOA was detected in 8.6% of M0 compared with 30.4% of M1 patients, and in 7.7% of hormone-sensitive compared with 27% of hormone/castration resistant PCa patients, associating it with bone metastasis and castration resistance. Multivariable regression analysis showed a correlation of MAOA with serum prostate-specific antigen, a marker for progression in PCa (Pearson correlation coefficient r = 0.30; P < 0.01). In patients with positive MAOA, there was overexpression of p38, phosphorylated-p38, c-Jun N-terminal kinases, phosphorylated c-Jun N-terminal kinases, nuclear factor kappa B, phosphorylated nuclear factor kappa B, transforming growth factor beta, vascular endothelial growth factor, interleukin 6, tumor necrosis factor α, Bcl-2 associated X, B-cell lymphoma 2, prostate-specific membrane antigen, and epithelial cell adhesion molecule in M1 compared with M0 group patients, associating these proteins with tumor burden. Overexpression of Bcl-2 associated X, tumor protein 53, c-Jun N-terminal kinases, nuclear factor kappa B, transforming growth factor beta, vascular endothelial growth factor, and prostate-specific membrane antigen and underexpression of B-cell lymphoma 2 and phosphorylated nuclear factor kappa B were observed in hormone-sensitive prostate cancer compared with hormone/castration-resistant prostate cancer, associating these proteins with castration resistance. Conclusions: Association of key molecules of oncogenesis and metastasis with MAOA suggests that MAOA inhibitors such as moclobemide might be effective in the management of PCa. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0011-393X |
| Relation: | http://www.sciencedirect.com/science/article/pii/S0011393X20300369; https://doaj.org/toc/0011-393X |
| DOI: | 10.1016/j.curtheres.2020.100610 |
| Access URL: | https://doaj.org/article/b18b4c6ca82f46c997751b16df844f7a |
| Accession Number: | edsdoj.b18b4c6ca82f46c997751b16df844f7a |
| Database: | Directory of Open Access Journals |
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| Items | – Name: Title Label: Title Group: Ti Data: Association of Monoamine Oxidase A with Tumor Burden and Castration Resistance in Prostate Cancer – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Meenakshi+Meenu%2C+MBBS%2C+MD%2C+DM%22">Meenakshi Meenu, MBBS, MD, DM</searchLink><br /><searchLink fieldCode="AR" term="%22Vipin+Kumar+Verma%2C+PhD%22">Vipin Kumar Verma, PhD</searchLink><br /><searchLink fieldCode="AR" term="%22Amlesh+Seth%2C+MBBS%2C+MS%2C+MCh%22">Amlesh Seth, MBBS, MS, MCh</searchLink><br /><searchLink fieldCode="AR" term="%22Ranjit+Kumar+Sahoo%2C+MBBS%2C+MD%2C+DM%22">Ranjit Kumar Sahoo, MBBS, MD, DM</searchLink><br /><searchLink fieldCode="AR" term="%22Pooja+Gupta%2C+MBBS%2C+MD%2C+DM%22">Pooja Gupta, MBBS, MD, DM</searchLink><br /><searchLink fieldCode="AR" term="%22Dharamvir+Singh+Arya%2C+MBBS%2C+MD%2C+PhD%22">Dharamvir Singh Arya, MBBS, MD, PhD</searchLink> – Name: TitleSource Label: Source Group: Src Data: Current Therapeutic Research, Vol 93, Iss , Pp 100610- (2020) – Name: Publisher Label: Publisher Information Group: PubInfo Data: Elsevier, 2020. – Name: DatePubCY Label: Publication Year Group: Date Data: 2020 – Name: Subset Label: Collection Group: HoldingsInfo Data: LCC:Therapeutics. Pharmacology – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Castration+resistance%22">Castration resistance</searchLink><br /><searchLink fieldCode="DE" term="%22Monoamine+oxidase+A%22">Monoamine oxidase A</searchLink><br /><searchLink fieldCode="DE" term="%22Prostate+cancer%22">Prostate cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+burden%22">Tumor burden</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%2E+Pharmacology%22">Therapeutics. Pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22RM1-950%22">RM1-950</searchLink> – Name: Abstract Label: Description Group: Ab Data: Background: Metastatic burden and aggressive behavior determine severity stratification and guide treatment decisions in prostate cancer (PCa). Monoamine oxidase A (MAOA) may promote tumor burden and drug/castration resistance in PCa. A positive association will pave the way for MAOA inhibitors such as moclobemide for PCa therapy. Objective: To analyze MAOA in peripheral blood mononuclear cells qualitatively and p38, c-Jun N-terminal kinases, nuclear factor kappa B, and their phosphorylated forms, vascular endothelial growth factor (angiogenesis), transforming growth factor beta, interleukin 6, and tumor necrosis factor-α (cytokines), Bcl-2 associated X, B-cell lymphoma 2, and P53 (apoptosis), prostate-specific membrane antigen, and epithelial cell adhesion molecules (surface markers) in plasma of patients with PCa. Methods: This was a 1-year pilot study in which patients with PCa were recruited and stratified into 2 groups and subgroups: treatment-naive with (M1) (n = 23) or without (M0) (n = 23) bone metastasis; hormone-sensitive prostate cancer (n = 26) or hormone/castration-resistant prostate cancer (n = 26). MAOA was detected using ELISA and other proteins were detected using immunoblotting technique. Results: MAOA was detected in 8.6% of M0 compared with 30.4% of M1 patients, and in 7.7% of hormone-sensitive compared with 27% of hormone/castration resistant PCa patients, associating it with bone metastasis and castration resistance. Multivariable regression analysis showed a correlation of MAOA with serum prostate-specific antigen, a marker for progression in PCa (Pearson correlation coefficient r = 0.30; P < 0.01). In patients with positive MAOA, there was overexpression of p38, phosphorylated-p38, c-Jun N-terminal kinases, phosphorylated c-Jun N-terminal kinases, nuclear factor kappa B, phosphorylated nuclear factor kappa B, transforming growth factor beta, vascular endothelial growth factor, interleukin 6, tumor necrosis factor α, Bcl-2 associated X, B-cell lymphoma 2, prostate-specific membrane antigen, and epithelial cell adhesion molecule in M1 compared with M0 group patients, associating these proteins with tumor burden. Overexpression of Bcl-2 associated X, tumor protein 53, c-Jun N-terminal kinases, nuclear factor kappa B, transforming growth factor beta, vascular endothelial growth factor, and prostate-specific membrane antigen and underexpression of B-cell lymphoma 2 and phosphorylated nuclear factor kappa B were observed in hormone-sensitive prostate cancer compared with hormone/castration-resistant prostate cancer, associating these proteins with castration resistance. Conclusions: Association of key molecules of oncogenesis and metastasis with MAOA suggests that MAOA inhibitors such as moclobemide might be effective in the management of PCa. – Name: TypeDocument Label: Document Type Group: TypDoc Data: article – Name: Format Label: File Description Group: SrcInfo Data: electronic resource – Name: Language Label: Language Group: Lang Data: English – Name: ISSN Label: ISSN Group: ISSN Data: 0011-393X – Name: NoteTitleSource Label: Relation Group: SrcInfo Data: http://www.sciencedirect.com/science/article/pii/S0011393X20300369; https://doaj.org/toc/0011-393X – Name: DOI Label: DOI Group: ID Data: 10.1016/j.curtheres.2020.100610 – Name: URL Label: Access URL Group: URL Data: <link linkTarget="URL" linkTerm="https://doaj.org/article/b18b4c6ca82f46c997751b16df844f7a" linkWindow="_blank">https://doaj.org/article/b18b4c6ca82f46c997751b16df844f7a</link> – Name: AN Label: Accession Number Group: ID Data: edsdoj.b18b4c6ca82f46c997751b16df844f7a |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.curtheres.2020.100610 Languages: – Text: English Subjects: – SubjectFull: Castration resistance Type: general – SubjectFull: Monoamine oxidase A Type: general – SubjectFull: Prostate cancer Type: general – SubjectFull: Tumor burden Type: general – SubjectFull: Therapeutics. Pharmacology Type: general – SubjectFull: RM1-950 Type: general Titles: – TitleFull: Association of Monoamine Oxidase A with Tumor Burden and Castration Resistance in Prostate Cancer Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Meenakshi Meenu, MBBS, MD, DM – PersonEntity: Name: NameFull: Vipin Kumar Verma, PhD – PersonEntity: Name: NameFull: Amlesh Seth, MBBS, MS, MCh – PersonEntity: Name: NameFull: Ranjit Kumar Sahoo, MBBS, MD, DM – PersonEntity: Name: NameFull: Pooja Gupta, MBBS, MD, DM – PersonEntity: Name: NameFull: Dharamvir Singh Arya, MBBS, MD, PhD IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Type: published Y: 2020 Identifiers: – Type: issn-print Value: 0011393X Numbering: – Type: volume Value: 93 – Type: issue Value: 100610- Titles: – TitleFull: Current Therapeutic Research Type: main |
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