Bibliographic Details
| Title: |
Evaluation of BAFF, APRIL and CD40L in Ocrelizumab-Treated pwMS and Infectious Risk |
| Authors: |
Maria Antonella Zingaropoli, Patrizia Pasculli, Matteo Tartaglia, Federica Dominelli, Federica Ciccone, Ambra Taglietti, Valentina Perri, Leonardo Malimpensa, Gina Ferrazzano, Marco Iannetta, Cosmo Del Borgo, Miriam Lichtner, Claudio Maria Mastroianni, Antonella Conte, Maria Rosa Ciardi |
| Source: |
Biology, Vol 12, Iss 4, p 587 (2023) |
| Publisher Information: |
MDPI AG, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Biology (General) |
| Subject Terms: |
pwMS, ocrelizumab, DMTs, anti-CD20, BAFF, APRIL, Biology (General), QH301-705.5 |
| More Details: |
Background: The anti-CD20 monoclonal antibody ocrelizumab has been widely employed in the treatment of people with multiple sclerosis (pwMS). However, its B-cell-depleting effect may induce a higher risk of infectious events and alterations in the secretion of B-cell-activating factors, such as BAFF, APRIL and CD40L. Methods: The aim of this study was to investigate plasma BAFF, APRIL and CD40L levels and their relationship with infectious risk in ocrelizumab-treated pwMS at baseline (T0), at 6 months (T6) and at 12 months (T12) after starting the treatment. As a control group, healthy donors (HD) were enrolled too. Results: A total of 38 pwMS and 26 HD were enrolled. At baseline, pwMS showed higher plasma BAFF (p < 0.0001), APRIL (p = 0.0223) and CD40L (p < 0.0001) levels compared to HD. Compared to T0, plasma BAFF levels were significantly increased at both T6 and T12 (p < 0.0001 and p < 0.0001, respectively). Whereas plasma APRIL and CD40L levels were decreased at T12 (p = 0.0003 and p < 0.0001, respectively). When stratifying pwMS according to the development of an infectious event during the 12-month follow-up period in two groups—with (14) and without an infectious event (24)—higher plasma BAFF levels were observed at all time-points; significantly, in the group with an infectious event compared to the group without an infectious event (T0: p < 0.0001, T6: p = 0.0056 and T12: p = 0.0400). Conclusions: BAFF may have a role as a marker of immune dysfunction and of infectious risk. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2079-7737 |
| Relation: |
https://www.mdpi.com/2079-7737/12/4/587; https://doaj.org/toc/2079-7737 |
| DOI: |
10.3390/biology12040587 |
| Access URL: |
https://doaj.org/article/b160963e955e4716a08664940f412a63 |
| Accession Number: |
edsdoj.b160963e955e4716a08664940f412a63 |
| Database: |
Directory of Open Access Journals |
