Academic Journal
NIR triggered polydopamine coated cerium dioxide nanozyme for ameliorating acute lung injury via enhanced ROS scavenging
| Title: | NIR triggered polydopamine coated cerium dioxide nanozyme for ameliorating acute lung injury via enhanced ROS scavenging |
|---|---|
| Authors: | Mingjing Yin, Doudou Lei, Yalan Liu, Tao Qin, Huyang Gao, Wenquan Lv, Qianyue Liu, Lian Qin, Weiqian Jin, Yin Chen, Hao Liang, Bailei Wang, Ming Gao, Jianfeng Zhang, Junyu Lu |
| Source: | Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-18 (2024) |
| Publisher Information: | BMC, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Biotechnology LCC:Medical technology |
| Subject Terms: | Acute lung injury, Nanozyme, ROS scavenging, M2 directional polarization, Synergistic enhanced therapy, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5 |
| More Details: | Abstract Acute lung injury (ALI) is a life threatening disease in critically ill patients, and characterized by excessive reactive oxygen species (ROS) and inflammatory factors levels in the lung. Multiple evidences suggest that nanozyme with diversified catalytic capabilities plays a vital role in this fatal lung injury. At present, we developed a novel class of polydopamine (PDA) coated cerium dioxide (CeO2) nanozyme (Ce@P) that acts as the potent ROS scavenger for scavenging intracellular ROS and suppressing inflammatory responses against ALI. Herein, we aimed to identify that Ce@P combining with NIR irradiation could further strengthen its ROS scavenging capacity. Specifically, NIR triggered Ce@P exhibited the most potent antioxidant and anti-inflammatory behaviors in lipopolysaccharide (LPS) induced macrophages through decreasing the intracellular ROS levels, down-regulating the levels of TNF-α, IL-1β and IL-6, up-regulating the level of antioxidant cytokine (SOD-2), inducing M2 directional polarization (CD206 up-regulation), and increasing the expression level of HSP70. Besides, we performed intravenous (IV) injection of Ce@P in LPS induced ALI rat model, and found that it significantly accumulated in the lung tissue for 6 h after injection. It was also observed that Ce@P + NIR presented the superior behaviors of decreasing lung inflammation, alleviating diffuse alveolar damage, as well as promoting lung tissue repair. All in all, it has developed the strategy of using Ce@P combining with NIR irradiation for the synergistic enhanced treatment of ALI, which can serve as a promising therapeutic strategy for the clinical treatment of ROS derived diseases as well. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1477-3155 |
| Relation: | https://doaj.org/toc/1477-3155 |
| DOI: | 10.1186/s12951-024-02570-w |
| Access URL: | https://doaj.org/article/eab09e3ac2a249649547062070238f9f |
| Accession Number: | edsdoj.b09e3ac2a249649547062070238f9f |
| Database: | Directory of Open Access Journals |
| Full text is not displayed to guests. | Login for full access. |
| ISSN: | 14773155 |
|---|---|
| DOI: | 10.1186/s12951-024-02570-w |
| Published in: | Journal of Nanobiotechnology |
| Language: | English |