| Title: |
Effects of Hericium erinaceu polysaccharide on microstructure, immune function, cell proliferation and apoptosis of thymus and spleen in LPS induced stressed mice |
| Authors: |
WANG Chenfang, DENG Juan, HAN Yujiao, GU Youfang, JIN Erhui, JIN Guangming |
| Source: |
Zhongguo shipin weisheng zazhi, Vol 34, Iss 3, Pp 482-490 (2022) |
| Publisher Information: |
The Editorial Office of Chinese Journal of Food Hygiene, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Food processing and manufacture
LCC:Nutrition. Foods and food supply |
| Subject Terms: |
hericium erinaceus polysaccharide, immune organs, microstructure, immune function, antioxidant function, cell proliferation and apoptosis, Food processing and manufacture, TP368-456, Nutrition. Foods and food supply, TX341-641 |
| More Details: |
ObjectiveTo study the effects of Hericium erinaceus polysaccharide on the microstructure， cytokine secretion， antioxidant function， cell proliferation and apoptosis of thymus and spleen in mice with immune stress induced by lipopolysaccharide （LPS）， so as to provide reference for the application of Hericium erinaceus polysaccharide in relieving stress.MethodsFifty male Kunming mice of 12-week old were randomly divided into control group， model group and experimental group I - III （n = 10）. In addition to the control group， the other four groups were intraperitoneally injected with 0.6 mL/kg/d LPS （once a day） three days before the end of the experiment. The experimental groups I， II and III were given 80， 160 and 320 mg/kg Hericium erinaceus polysaccharide by gavage for 2 weeks.ResultsCompared with the control group， the levels of interleukin-1 β （IL-1β）， interleukin-4 （IL-4） and interferon γ （IFN- γ） in thymus and spleen of mice in the model group were significantly increased （P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
Chinese |
| ISSN: |
1004-8456 |
| Relation: |
http://www.zgspws.com/zgspwszz/article/abstract/202203014?st=article_issue; https://doaj.org/toc/1004-8456 |
| DOI: |
10.13590/j.cjfh.2022.03.014 |
| Access URL: |
https://doaj.org/article/b02eeb77aa264ce7b48874ffc8932e85 |
| Accession Number: |
edsdoj.b02eeb77aa264ce7b48874ffc8932e85 |
| Database: |
Directory of Open Access Journals |
