A Natural Autophagy Activator Castanea crenata Flower Alleviates Skeletal Muscle Ageing
| Title: | A Natural Autophagy Activator Castanea crenata Flower Alleviates Skeletal Muscle Ageing |
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| Authors: | So‐Hyun Park, Pyeong Geun Choi, Hee‐Soo Kim, Eunyoung Lee, Da‐Hye Lee, Min Jung Kim, Daedong Kim, Hyo‐Deok Seo, Jeong‐Hoon Hahm, Tae‐Il Jeon, Yang‐Hoon Huh, Jiyun Ahn, Tae‐Youl Ha, Chang Hwa Jung |
| Source: | Journal of Cachexia, Sarcopenia and Muscle, Vol 16, Iss 1, Pp n/a-n/a (2025) |
| Publisher Information: | Wiley, 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Diseases of the musculoskeletal system LCC:Human anatomy |
| Subject Terms: | AMPK, autophagy, Castanea crenata flower, protein acetylation, sarcophenia, Diseases of the musculoskeletal system, RC925-935, Human anatomy, QM1-695 |
| More Details: | ABSTRACT Background Sarcopenia, characterized by a gradual decline in skeletal muscle mass and function with age, significantly impacts both quality of life and mortality. Autophagy plays a crucial role in maintaining muscle health. There is growing interest in leveraging autophagy to mitigate muscle ageing effects. The impact of natural autophagy activators on skeletal muscle ageing remains elusive. This study aims to identify natural autophagy activators and assess their effects on skeletal muscle ageing. Methods To discover novel autophagy activators, we screened 493 natural products and identified Castanea crenata flower extract (CCFE) as a promising candidate. We investigated the effect of CCFE on cellular senescence in C2C12 cells induced by etoposide. In animal experiments, aged mice (18 months old) were fed a diet supplemented with 0.1% and 0.2% CCFE for 3 months. We assessed exercise capacity, mitochondrial function and autophagic flux to determine the impact of CCFE on skeletal muscle ageing. The components present in CCFE were analysed using LC‐MS/MS, and their functional properties were examined. Results CCFE enhanced autophagic flux (LC3II 80% increase, p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2190-6009 2190-5991 |
| Relation: | https://doaj.org/toc/2190-5991; https://doaj.org/toc/2190-6009 |
| DOI: | 10.1002/jcsm.13710 |
| Access URL: | https://doaj.org/article/b02bb5189e894ecfa6778831c3e1e589 |
| Accession Number: | edsdoj.b02bb5189e894ecfa6778831c3e1e589 |
| Database: | Directory of Open Access Journals |
| ISSN: | 21906009 21905991 |
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| DOI: | 10.1002/jcsm.13710 |
| Published in: | Journal of Cachexia, Sarcopenia and Muscle |
| Language: | English |