Elevated Adipsin and Reduced C5a Levels in the Maternal Serum and Follicular Fluid During Implantation Are Associated With Successful Pregnancy in Obese Women
| Title: | Elevated Adipsin and Reduced C5a Levels in the Maternal Serum and Follicular Fluid During Implantation Are Associated With Successful Pregnancy in Obese Women |
|---|---|
| Authors: | Manjunath Ramanjaneya, Ilhame Diboun, Najeha Rizwana, Yaser Dajani, Lina Ahmed, Alexandra E. Butler, Thoraya Ali Almarzooqi, Mohammed Shahata, Moza Khalaf Al Bader, Einas Elgassim, Hasan Burjaq, Stephen L. Atkin, Abdul-Badi Abou-Samra, Mohamed A. Elrayess |
| Source: | Frontiers in Endocrinology, Vol 13 (2022) |
| Publisher Information: | Frontiers Media S.A., 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: | adipsin, follicular fluid (FF), in vitro fertilization (IVF), complement factors, embryos, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: | IntroductionComplement factors mediate the recruitment and activation of immune cells and are associated with metabolic changes during pregnancy. The aim of this study was to determine whether complement factors in the maternal serum and follicular fluid (FF) are associated with in vitro fertilization (IVF) outcomes in overweight/obese women.MethodsForty overweight/obese (BMI = 30.8 ± 5.2 kg/m2) female patients, 33.6 ± 6.3 years old, undergoing IVF treatment for unexplained infertility were recruited. Baseline demographic information, including biochemical hormonal, metabolic, and inflammatory markers, and pregnancy outcome, was collected. Levels of 14 complement markers (C2, C4b, C5, C5a, C9, adipsin, mannose-binding lectin, C1q, C3, C3b/iC3b, C4, factor B, factor H, and properdin) were assessed in the serum and FF and compared to IVF outcome, inflammatory, and metabolic markers using multivariate and univariate models.ResultsOut of 40 IVF cycles, 14 (35%) resulted in pregnancy. Compared to women with failed pregnancies, women with successful pregnancies had higher levels of adipsin in the serum and FF (p = 0.01) but lower C5a levels (p = 0.05). Serum adipsin levels were positively correlated with circulating levels of vitamin D (R = 0.5, p = 0.02), glucagon (R = 0.4, p = 0.03), leptin (R = 0.4, p = 0.01), resistin (R = 0.4, p = 0.02), and visfatin (R = 0.4, p = 0.02), but negatively correlated with total protein (R = −0.5, p = 0.03). Higher numbers of top-quality embryos were associated with increased levels of C3, properdin, C1q, factors H and B, C4, and adipsin, but with reduced C2 and C5a levels (p ≤ 0.01).ConclusionsHigher adipsin and lower C5a levels in the maternal serum during implantation are potential markers of successful outcome in obese women undergoing IVF-assisted pregnancies. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1664-2392 03993078 |
| Relation: | https://www.frontiersin.org/articles/10.3389/fendo.2022.918320/full; https://doaj.org/toc/1664-2392 |
| DOI: | 10.3389/fendo.2022.918320 |
| Access URL: | https://doaj.org/article/9fcf8abb749a4988b0399307891a0b56 |
| Accession Number: | edsdoj.9fcf8abb749a4988b0399307891a0b56 |
| Database: | Directory of Open Access Journals |
| ISSN: | 16642392 03993078 |
|---|---|
| DOI: | 10.3389/fendo.2022.918320 |
| Published in: | Frontiers in Endocrinology |
| Language: | English |