Bibliographic Details
| Title: |
MAP7D2 Localizes to the Proximal Axon and Locally Promotes Kinesin-1-Mediated Cargo Transport into the Axon |
| Authors: |
Xingxiu Pan, Yujie Cao, Riccardo Stucchi, Peter Jan Hooikaas, Sybren Portegies, Lena Will, Maud Martin, Anna Akhmanova, Martin Harterink, Casper C. Hoogenraad |
| Source: |
Cell Reports, Vol 26, Iss 8, Pp 1988-1999.e6 (2019) |
| Publisher Information: |
Elsevier, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Biology (General) |
| Subject Terms: |
Biology (General), QH301-705.5 |
| More Details: |
Summary: The motor protein kinesin-1 plays an important role in polarized sorting of transport vesicles to the axon. However, the mechanism by which the axonal entry of kinesin-1-dependent cargo transport is regulated remains unclear. Microtubule-associated protein MAP7 (ensconsin in Drosophila) is an essential kinesin-1 cofactor and promotes kinesin-1 recruitment to microtubules. Here, we found that MAP7 family member MAP7D2 concentrates at the proximal axon, where it overlaps with the axon initial segment and interacts with kinesin-1. Depletion of MAP7D2 results in reduced axonal cargo entry and defects in axon development and neuronal migration. We propose a model in which MAP7D2 in the proximal axon locally promotes kinesin-1-mediated cargo entry into the axon. : Kinesin-1 is well known for transporting vesicles and organelles into to the axon. Pan et al. show that MAP7D2 concentrates at the proximal axon, regulates kinesin-1 activity, and locally promotes kinesin-1-mediated cargo trafficking into axons. Specific microtubule-associated proteins (MAPs) that locally control motor activities is an emerging concept. Keywords: microtubule, microtubule-associated protein, kinesin, axon initial segment, transport |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2211-1247 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2211124719301202; https://doaj.org/toc/2211-1247 |
| DOI: |
10.1016/j.celrep.2019.01.084 |
| Access URL: |
https://doaj.org/article/9f9da2bb1c7f42358fc76d0bb724690a |
| Accession Number: |
edsdoj.9f9da2bb1c7f42358fc76d0bb724690a |
| Database: |
Directory of Open Access Journals |
