Prevalence of endothelial dysfunction and increased vascular stiffness in patients with solid malignancies
| Title: | Prevalence of endothelial dysfunction and increased vascular stiffness in patients with solid malignancies |
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| Authors: | Olga V. Andreeva, Nikolai N. Semenov, Dmitry Y. Shchekochikhin, Alena I. Novikova, Nadezhda A. Potemkina, Maryana A. Ozova, Zubeida A. Kuli-Zade, Victoria D. Levina, Anna A. Shmeleva, Maria G. Poltavskaya |
| Source: | Alʹmanah Kliničeskoj Mediciny, Vol 50, Iss 2, Pp 103-110 (2022) |
| Publisher Information: | MONIKI, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Medicine |
| Subject Terms: | endothelial dysfunction, arterial stiffness, cardiooncology, malignant neoplasms, pulse wave rate, cancer, occlusion test, Medicine |
| More Details: | Background: Endothelial dysfunction is recognized as one of the early markers of cardiovascular disorders. It is supposed to be a potential predictor of cardiovascular complications in patients receiving adjuvant and neoadjuvant chemotherapy. Aim: To estimate the prevalence of endothelial dysfunction in solid cancer patients compared to that in individuals without any malignancies. Materials and methods: This observational study included 74 patients with solid malignancies, mostly gastrointestinal. Prior to polychemotherapy, all patients were examined for endothelial function of small and large arteries (AngioScan-01, Fiton, Russia) and peripheral artery stiffness (pulse wave contour analysis and occlusion test). The results were compared with those of the Russian population trials of endothelial dysfunction Meridian-RO (Ryazan region) and trial in the rural population of the Krasnodar region. Results: Compromised vasodilation and smaller arteries tone were found in 64.9% (48/74) of the cancer patients, while impaired vasodilation of larger muscular arteries was present in 94.6% (70/74) of the patients. According to the Meridian-RO trial in the Ryazan region, endothelial dysfunction had been found in 51.2% (n = 341) of women and 52.4% (n = 300) of men, whereas the Krasnodar regional population data had shown it in 68.4% (n = 353) of women and 71.7% (n = 253) of men. Conclusion: The prevalence of endothelial dysfunction in the patients with solid malignancies, who have not undergone any chemo- or radiation therapy, is significantly higher than in the population of comparable age, conventional cardiovascular risk factors, and comorbidities. No significant increase of vascular stiffness was identified. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | Russian |
| ISSN: | 2072-0505 2587-9294 |
| Relation: | https://almclinmed.ru/jour/article/viewFile/1600/1463; https://doaj.org/toc/2072-0505; https://doaj.org/toc/2587-9294 |
| DOI: | 10.18786/2072-0505-2022-50-022 |
| Access URL: | https://doaj.org/article/9f5ea695055347629e59668476c5b7ab |
| Accession Number: | edsdoj.9f5ea695055347629e59668476c5b7ab |
| Database: | Directory of Open Access Journals |
| ISSN: | 20720505 25879294 |
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| DOI: | 10.18786/2072-0505-2022-50-022 |
| Published in: | Alʹmanah Kliničeskoj Mediciny |
| Language: | Russian |