Antioxidant and Acetylcholinesterase Inhibitor Potentials of the Stem Extract of Pternandra galeata
| Title: | Antioxidant and Acetylcholinesterase Inhibitor Potentials of the Stem Extract of Pternandra galeata |
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| Authors: | Suciati Suciati, Dwiki Nur Inayah, Aty Widyawaruyanti, Rudiyansyah Rudiyansyah |
| Source: | Vitae, Vol 29, Iss 3 (2022) |
| Publisher Information: | Universidad de Antioquia, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Food processing and manufacture LCC:Pharmaceutical industry |
| Subject Terms: | Pternandra galeata, Alzheimer's disease, Acetylcholinesterase inhibitor, Antioxidant, Phenolic compounds, Food processing and manufacture, TP368-456, Pharmaceutical industry, HD9665-9675 |
| More Details: | Background: Pternandra galeata belongs to the family Melastomataceae. It is a native flowering plant in Borneo Island that serve as food for monkey habitat. There has been limited study on the medicinal and chemical properties of this plant. Objectives: We investigated the acetylcholinesterase inhibitory activity and evaluated the antioxidant activity of the ethanolic extract of Pternandra galeata stem. The total phenolic content in the sample was also determined. Methods: The acetylcholinesterase inhibitory assays were performed using Ellman’s method. Two different methods were used to evaluate the antioxidant activity of 2,2-diphenyl-1-picryl hydrazyl (DPPH) and 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. The total phenolic content was determined by the Folin-Ciocalteu method by employing gallic acid as a reference. Results: The ethanolic extract of the P. galeata stems inhibited the AChE enzyme with an IC50value of 74.62 ± 0.89 µg/mL. The sample exhibited antioxidant activity in the DPPH assay with an IC50 value of 20.21 ± 0.08 µg/mL and 7.68 ± 0.09µg/mL in the ABTS scavenging assay. The total phenolic content was 164.71 ± 3.33 mg GAE/g extract. Conclusion: The ethanolic extract of the P. galeata stem can be a promising cholinesterase inhibitor and antioxidant for treating Alzheimer’s disease. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0121-4004 2145-2660 |
| Relation: | https://revistas.udea.edu.co/index.php/vitae/article/view/349983; https://doaj.org/toc/0121-4004; https://doaj.org/toc/2145-2660 |
| DOI: | 10.17533/udea.vitae.v29n3a349983 |
| Access URL: | https://doaj.org/article/9f36219bee544ff592b434322b5a4018 |
| Accession Number: | edsdoj.9f36219bee544ff592b434322b5a4018 |
| Database: | Directory of Open Access Journals |
| ISSN: | 01214004 21452660 |
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| DOI: | 10.17533/udea.vitae.v29n3a349983 |
| Published in: | Vitae |
| Language: | English |