Academic Journal
Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency
| Title: | Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency |
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| Authors: | Alejandro Álvarez-Quilón, José Terrón-Bautista, Irene Delgado-Sainz, Almudena Serrano-Benítez, Rocío Romero-Granados, Pedro Manuel Martínez-García, Silvia Jimeno-González, Cristina Bernal-Lozano, Cristina Quintero, Lourdes García-Quintanilla, Felipe Cortés-Ledesma |
| Source: | Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
| Publisher Information: | Nature Portfolio, 2020. |
| Publication Year: | 2020 |
| Collection: | LCC:Science |
| Subject Terms: | Science |
| More Details: | The ATM kinase is a key regulator of the DNA damage response to double-strand breaks (DSBs) and its homozygous loss in patients predisposes to lymphoid malignancies. Here, the authors develop a Tdp2 −/− Atm −/− double-deficient mouse model to uncover topoisomerase II-induced DSBs as significant drivers of the genomic rearrangements that underpin these tumours. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2041-1723 16766628 |
| Relation: | https://doaj.org/toc/2041-1723 |
| DOI: | 10.1038/s41467-020-14638-w |
| Access URL: | https://doaj.org/article/9f1676662817487ea864a82ec0a5a86d |
| Accession Number: | edsdoj.9f1676662817487ea864a82ec0a5a86d |
| Database: | Directory of Open Access Journals |
| ISSN: | 20411723 16766628 |
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| DOI: | 10.1038/s41467-020-14638-w |
| Published in: | Nature Communications |
| Language: | English |